Drugs Details

Drugs Info of Bactroban Nasal
Drugs Details
  • Drugs Type  : Multum
  • Date : 26th Dec 2014 09:57 pm
  • Brand Name : Bactroban Nasal
  • Generic Name : mupirocin nasal (Pronunciation: mue PIR oh sin)
Descriptions

BACTROBAN NASAL (mupirocin calcium ointment, 2%) contains the dihydrate crystalline calcium hemi-salt of the antibiotic mupirocin. Chemically, it is (αE,2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-β-methyl-2H-pyran-2-crotonic acid, ester with 9-hydroxynonanoic acid, calcium salt (2:1), dihydrate.

The molecular formula of mupirocin calcium is (C26H43O9)2Ca•2H2O, and the molecular weight is 1075.3. The molecular weight of mupirocin free acid is 500.6. The structural formula of mupirocin calcium is:

 

View Enlarged Table

BACTROBAN NASAL (mupirocin calcium ointment) is a white to off-white ointment that contains 2.15% w/w mupirocin calcium (equivalent to 2.0% pure mupirocin free acid) in a soft white ointment base. The inactive ingredients are paraffin and a mixture of glycerin esters (SOFTISAN® 649).

What are the possible side effects of mupirocin nasal (Bactroban)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using mupirocin nasal and call your doctor at once if you have a serious side effect such as:

  • nosebleed; or
  • severe burning or stinging of your nose.

Less serious side effects may include:

  • dryness or unpleasant taste in your mouth;
  • headache;
  • ear pain;
  • runny or stuffy nose;
  • nausea, diarrhea;
  • itching, mild skin rash;
  • cough;...

Read All Potential Side Effects and See Pictures of Bactroban Nasal »

What are the precautions when taking mupirocin calcium ointment (Bactroban Nasal)?

Before taking mupirocin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Bactroban Nasal »

This monograph has been modified to include the generic and brand name in many instances.

Indications

BACTROBAN NASAL (mupirocin calcium ointment) is indicated for the eradication of nasal colonization with methicillin-resistant S. aureus in adult patients and health care workers as part of a comprehensive infection control program to reduce the risk of infection among patients at high risk of methicillin-resistant S. aureus infection during institutional outbreaks of infections with this pathogen.

NOTE:

  1. There are insufficient data at this time to establish that this product is safe and effective as part of an intervention program to prevent autoinfection of high-risk patients from their own nasal colonization with S. aureus.
  2. There are insufficient data at this time to recommend use of BACTROBAN NASAL (mupirocin calcium ointment) for general prophylaxis of any infection in any patient population.
  3. Greater than 90% of subjects/patients in clinical trials had eradication of nasal colonization 2 to 4 days after therapy was completed. Approximately 30% recolonization was reported in 1 domestic study within 4 weeks after completion of therapy. These eradication rates were clinically and statistically superior to those reported in subjects/patients in the vehicle-treated arms of the adequate and well-controlled studies. Those treated with vehicle had eradication rates of 5% to 30% at 2 to 4 days post-therapy with 85% to 100% recolonization within 4 weeks.

All adequate and well-controlled trials of this product were vehicle-controlled; therefore, no data from direct, head-to-head comparisons with other products are available at this time.

DOSAGE AND ADMINISTRATION

(See INDICATIONS.)

Adults (12 years of age and older): Approximately one-half of the ointment from the single-use tube should be applied into 1 nostril and the other half into the other nostril twice daily (morning and evening) for 5 days.

After application, the nostrils should be closed by pressing together and releasing the sides of the nose repetitively for approximately 1 minute. This will spread the ointment throughout the nares.

The single-use 1.0 gram tube will deliver a total of approximately 0.5 grams of the ointment (approximately 0.25 grams/nostril).

The tube should be discarded after usage; it should not be re-used.

The safety and effectiveness of applications of this medication for greater than 5 days have not been established. There are no human clinical or pre-clinical animal data to support the use of this product in a chronic manner or in manners other than those described in this package insert.

Until further information is known, BACTROBAN NASAL (mupirocin calcium ointment) should not be applied concurrently with any other intranasal products.

HOW SUPPLIED

BACTROBAN NASAL (mupirocin calcium ointment) is supplied in 1.0-gram tubes packaged in cartons of 10.

NDC 0029-1526-11 (1.0 gram tubes in packages of 10).

Store between 20° and 25°C (68° and 77°F); excursions permitted to 15°-30°C (59°-86°F).

Do not refrigerate.

REFERENCE

1. Clinical and Laboratory Standards Institute (CLSI) (formerly the National Committee for Clinical Laboratory Standards). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Approved Standard. CLSI Document M7-A7. CLSI, Wayne, PA, January 2006.

GlaxoSmithKline, Research Triangle Park, NC 27709. June 2007. FDA Rev date: 11/15/2001

This monograph has been modified to include the generic and brand name in many instances.

Dosage Administration

(See INDICATIONS.)

Adults (12 years of age and older): Approximately one-half of the ointment from the single-use tube should be applied into 1 nostril and the other half into the other nostril twice daily (morning and evening) for 5 days.

After application, the nostrils should be closed by pressing together and releasing the sides of the nose repetitively for approximately 1 minute. This will spread the ointment throughout the nares.

The single-use 1.0 gram tube will deliver a total of approximately 0.5 grams of the ointment (approximately 0.25 grams/nostril).

The tube should be discarded after usage; it should not be re-used.

The safety and effectiveness of applications of this medication for greater than 5 days have not been established. There are no human clinical or pre-clinical animal data to support the use of this product in a chronic manner or in manners other than those described in this package insert.

Until further information is known, BACTROBAN NASAL (mupirocin calcium ointment) should not be applied concurrently with any other intranasal products.

How Supplied

BACTROBAN NASAL (mupirocin calcium ointment) is supplied in 1.0-gram tubes packaged in cartons of 10.

NDC 0029-1526-11 (1.0 gram tubes in packages of 10).

Store between 20° and 25°C (68° and 77°F); excursions permitted to 15°-30°C (59°-86°F).

Do not refrigerate.

REFERENCE

1. Clinical and Laboratory Standards Institute (CLSI) (formerly the National Committee for Clinical Laboratory Standards). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Approved Standard. CLSI Document M7-A7. CLSI, Wayne, PA, January 2006.

GlaxoSmithKline, Research Triangle Park, NC 27709. June 2007. FDA Rev date: 11/15/2001

This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Clinical Trials: In clinical trials, 210 domestic and 2,130 foreign adult subjects/patients received BACTROBAN NASAL (mupirocin calcium ointment) ointment. Less than 1% of domestic or foreign subjects and patients in clinical trials were withdrawn due to adverse events.

The most frequently reported adverse events in foreign clinical trials were as follows: rhinitis (1.0%), taste perversion (0.8%), pharyngitis (0.5%).

In domestic clinical trials, 17% (36/210) of adults treated with BACTROBAN NASAL ointment reported adverse events thought to be at least possibly drug-related. The incidence of adverse events that were reported in at least 1% of adults enrolled in domestic clinical trials were as follows:

ADVERSE EVENTS ( ≥ 1% INCIDENCE)-ADULTS IN US TRIALS

  % of Subjects/Patients Experiencing Event
BACTROBAN NASAL (mupirocin calcium ointment)
(n=210)
Headache 9%
Rhinitis 6%
Respiratory disorder, including upper respiratory tract congestion 5%
Pharyngitis 4%
Taste perversion 3%
Burning/stinging 2%
Cough 2%
Pruritus 1%

The following events thought possibly drug-related were reported in less than 1% of adults enrolled in domestic clinical trials: Blepharitis, diarrhea, dry mouth, ear pain, epistaxis, nausea, and rash.

All adequate and well-controlled clinical trials have been performed using BACTROBAN NASAL (mupirocin calcium ointment) ointment, 2% in 1 arm and the vehicle ointment in the other arm of the study. No adequate and well-controlled safety data are available from direct, head-to-head comparative studies of this product and other products for this indication.

Read the Bactroban Nasal (mupirocin calcium ointment) Side Effects Center for a complete guide to possible side effects

Interactions

The effect of the concurrent application of intranasal mupirocin calcium and other intranasal products has not been studied. Until further information is known, mupirocin calcium ointment, 2% should not be applied concurrently with any other intranasal products. Carcinogenesis, Mutagenesis, Impairment of Fertility: Long-term studies in animals to evaluate carcinogenic potential of mupirocin calcium have not been conducted.

Results of the following studies performed with mupirocin calcium or mupirocin sodium in vitro and in vivo did not indicate a potential for mutagenicity: Rat primary hepatocyte unscheduled DNA synthesis, sediment analysis for DNA strand breaks, Salmonella reversion test (Ames), Escherichia coli mutation assay, metaphase analysis of human lymphocytes, mouse lymphoma assay, and bone marrow micronuclei assay in mice.

Reproduction studies were performed in rats with mupirocin administered subcutaneously at doses up to 40 times the human intranasal dose (approximately 20 mg mupirocin per day) on a mg/m2 basis and revealed no evidence of impaired fertility from mupirocin sodium.

This monograph has been modified to include the generic and brand name in many instances.

Warnings

AVOID CONTACT WITH THE EYES. Application of BACTROBAN NASAL (mupirocin calcium ointment) to the eye under testing conditions has caused severe symptoms such as burning and tearing. These symptoms resolved within days to weeks after discontinuation of the ointment.

In the event of a sensitization or severe local irritation from BACTROBAN NASAL (mupirocin calcium ointment) , usage should be discontinued.

Precautions

General: As with other antibacterial products, prolonged use may result in overgrowth of nonsusceptible microorganisms, including fungi. (See DOSAGE AND ADMINISTRATION.)

Pregnancy

Teratogenic Effects

Pregnancy Category B: Reproduction studies have been performed in rats and rabbits with mupirocin administered subcutaneously at doses up to 65 and 130 times, respectively, the human intranasal dose (approximately 20 mg mupirocin per day) on a mg/m2 basis and revealed no evidence of harm to the fetus due to mupirocin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when BACTROBAN NASAL (mupirocin calcium ointment) is administered to a nursing woman.

Pediatric Use

Safety in children under the age of 12 years has not been established. (See CLINICAL PHARMACOLOGY.)

This monograph has been modified to include the generic and brand name in many instances.

OverDose

Following single or repeated intranasal applications of BACTROBAN NASAL (mupirocin calcium ointment) to adults, no evidence for systemic absorption of mupirocin was obtained. Intravenous infusions of 252 mg, as well as single oral doses of 500 mg of mupirocin, have been well tolerated in healthy adult subjects. There is no information regarding local overdose of BACTROBAN NASAL (mupirocin calcium ointment) or regarding oral ingestion of the nasal ointment formulation.

ContrainDications

BACTROBAN NASAL (mupirocin calcium ointment) is contraindicated in patients with known hypersensitivity to any of the constituents of the product.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

Pharmacokinetics

Following single or repeated intranasal applications of 0.2 gram of BACTROBAN NASAL (mupirocin calcium ointment) 3 times daily for 3 days to 5 healthy adult male subjects, no evidence of systemic absorption of mupirocin was demonstrated. The dosage regimen used in this study was for pharmacokinetic characterization only. (See DOSAGE AND ADMINISTRATION for proper clinical dosing information.)

In this study, the concentrations of mupirocin in urine and of monic acid in urine and serum were below the limit of determination of the assay for up to 72 hours after the applications. The lowest levels of determination of the assay used were 50 ng/mL of mupirocin in urine, 75 ng/mL of monic acid in urine, and 10 ng/mL of monic acid in serum. Based on the detectable limit of the urine assay for monic acid, one can extrapolate that a mean of 3.3% (range: 1.2 to 5.1%) of the applied dose could be systemically absorbed from the nasal mucosa of adults.

Data from a report of a pharmacokinetic study in neonates and premature infants indicate that, unlike in adults, significant systemic absorption occurred following intranasal administration of BACTROBAN NASAL (mupirocin calcium ointment) in this population. At this time, the pharmacokinetic properties of mupirocin following intranasal application of BACTROBAN NASAL (mupirocin calcium ointment) have not been adequately characterized in neonates or other children less than 12 years of age, and in addition, the safety of the product in children less than 12 years of age has not been established.

The effect of the concurrent application of intranasal mupirocin calcium ointment, 2% with other intranasal products has not been studied. (See PRECAUTIONS: DRUG INTERACTIONS)

Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite, monic acid, demonstrates no antibacterial activity. In a study conducted in 7 healthy adult male subjects, the elimination half-life after intravenous administration of mupirocin was 20 to 40 minutes for mupirocin and 30 to 80 minutes for monic acid. Monic acid is predominantly eliminated by renal excretion. The pharmacokinetics of mupirocin has not been studied in individuals with renal insufficiency.

Microbiology

Mupirocin is an antibacterial agent produced by fermentation using the organism Pseudomonas fluorescens. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. Due to this mode of action, mupirocin demonstrates no in vitro cross-resistance with other classes of antimicrobial agents.

When mupirocin resistance does occur, it appears to result from the production of a modified isoleucyl-tRNA synthetase. High-level plasmid-mediated resistance (MIC > 1,024 mcg/mL) has been reported in some strains of Staphylococcus aureus and coagulase-negative staphylococci.

Mupirocin is bactericidal at concentrations achieved topically by intranasal administration. However, the minimum bactericidal concentration (MBC) against relevant intranasal pathogens is generally 8-fold to 30-fold higher than the minimum inhibitory concentration (MIC). In addition, mupirocin is highly protein bound ( > 97%), and the effect of nasal secretions on the MICs of intranasally applied mupirocin has not been determined.

Mupirocin has been shown to be active against most strains of methicillin-resistant S. aureus, both in vitro and in clinical studies of the eradication of nasal colonization. BACTROBAN NASAL (mupirocin calcium ointment) only has established clinical utility in nasal eradication as part of a comprehensive program to curtail institutional outbreaks of infections with methicillin-resistant S. aureus. (See INDICATIONS)

The following in vitro data are available, but their clinical significance is unknown.

Mupirocin exhibits in vitro MICs of 1 mcg/mL or less against most ( > 90%) strains of methicillin-susceptible S. aureus; however, the safety and effectiveness of mupirocin calcium in eradicating nasal colonization of and preventing subsequent infections due to methicillin-susceptible S. aureus have not been established.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

Patients should be given the following instructions:

  • Apply approximately one-half of the ointment from the single-use tube directly into 1 nostril and the other half into the other nostril;
  • Avoid contact of the medication with the eyes;
  • Discard the tube after using, do not re-use;
  • Press the sides of the nose together and gently massage after application to spread the ointment throughout the inside of the nostrils; and
  • Discontinue usage of the medication and call your health care practitioner if sensitization or severe local irritation occurs.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

 

MUPIROCIN - NASAL OINTMENT

 

(myou-PEER-oh-sin)

 

COMMON BRAND NAME(S): Bactroban Nasal

 

USES: Mupirocin is used to temporarily get rid of certain nasal bacteria as part of an infection control program. It is an antibiotic that works by stopping the growth of certain bacteria.

 

HOW TO USE: Apply half of the tube's contents to one nostril and the other half to the other nostril, usually in the morning and evening, or as directed by your doctor. Then gently squeeze your nostrils together and release. Repeat this for about 1 minute to spread the ointment. Throw away the tube after applying to both nostrils.

Use this medication regularly in order to get the most benefit from it. Continue to use it for the full amount of time prescribed. Stopping this medication too early may allow bacteria to continue to grow.

Avoid contact with your eyes.

The manufacturer recommends not to use this medication with any other nasal products.

Consumer Overview Side Effect

SIDE EFFECTS: Headache, stuffy nose, sore throat, bad taste in the mouth, burning/stinging of the nose, or cough may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Seek immediate medical attention if a rash or severe itching occurs.

Use of this medication for prolonged or repeated periods may result in a new infection (e.g., fungal infection). Contact your doctor if you notice signs of a new infection.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

 

Read the Bactroban Nasal (mupirocin calcium ointment) Side Effects Center for a complete guide to possible side effects

Learn More »

PRECAUTIONS: Before taking mupirocin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Consumer Overview Missed Dose

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: chloramphenicol, other nasal products.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

 

OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. This medicine may be harmful if swallowed.

 

NOTES: Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in those cases.

 

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

 

STORAGE: Store at or below 77 degrees F (25 degrees C). Do not freeze. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.

Patient Detailed Side Effect

Brand Names: Bactroban

Generic Name: mupirocin nasal (Pronunciation: mue PIR oh sin)

  • What is mupirocin nasal (Bactroban Nasal)?
  • What are the possible side effects of mupirocin nasal (Bactroban Nasal)?
  • What is the most important information I should know about mupirocin nasal (Bactroban Nasal)?
  • What should I discuss with my health care provider before using mupirocin nasal (Bactroban Nasal)?
  • How should I use mupirocin nasal (Bactroban Nasal)?
  • What happens if I miss a dose (Bactroban Nasal)?
  • What happens if I overdose (Bactroban Nasal)?
  • What should I avoid while using mupirocin nasal (Bactroban Nasal)?
  • What other drugs will affect mupirocin nasal (Bactroban Nasal)?
  • Where can I get more information?

What is mupirocin nasal (Bactroban Nasal)?

Mupirocin is an antibiotic that treats or prevents infection caused by bacteria.

Mupirocin nasal (for the nose) is used to treat bacteria in the nostrils of patients and healthcare workers during an outbreak of severe staph infection within a hospital or other medical setting. This can help prevent the growth of staph bacteria in patients with a high risk of infection.

Mupirocin nasal may also be used for purposes not listed in this medication guide.

Bactroban Nasal

What are the possible side effects of mupirocin nasal (Bactroban Nasal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using mupirocin nasal and call your doctor at once if you have a serious side effect such as:

  • nosebleed; or
  • severe burning or stinging of your nose.

Less serious side effects may include:

  • dryness or unpleasant taste in your mouth;
  • headache;
  • ear pain;
  • runny or stuffy nose;
  • nausea, diarrhea;
  • itching, mild skin rash;
  • cough; or
  • sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Bactroban Nasal (mupirocin calcium ointment) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about mupirocin nasal (Bactroban Nasal)?

Mupirocin nasal is usually given for 5 days. To best protect you from infection, use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Stop using mupirocin nasal and call your doctor at once if you have severe burning or stinging of your nose.

Avoid getting this medication in your eyes. If this does happen, rinse with water.

Do not use other nasal medications during treatment with mupirocin nasal unless your doctor tells you to.

Side Effects Centers
  • Bactroban Nasal

Patient Detailed How Take

What should I discuss with my health care provider before using mupirocin nasal (Bactroban Nasal)?

You should not use this medication if you are allergic to mupirocin.

FDA pregnancy category B. Mupirocin nasal is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether mupirocin nasal passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Mupirocin nasal should not be used in a child younger than 12 years old.

How should I use mupirocin nasal (Bactroban Nasal)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Mupirocin nasal ointment is packaged in single-use tubes. Use one half of the medicine from the tube in your left nostril, and use the other half in your right nostril. After placing the ointment into your nostrils, gently press your nostrils closed and then release them, repeating for about 1 minute to help spread the ointment inside your nose.

Each single-use tube of ointment is for one use only. Throw away after one use, even if there is still some medicine left in it.

Mupirocin nasal is usually given for 5 days. To best protect you from infection, use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Mupirocin will not treat or prevent a viral infection such as the common cold or flu.

Store at room temperature away from moisture and heat. Do not refrigerate.

Side Effects Centers
  • Bactroban Nasal

Patient Detailed Avoid Taking

What happens if I miss a dose (Bactroban Nasal)?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose (Bactroban Nasal)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while using mupirocin nasal (Bactroban Nasal)?

Avoid getting this medication in your eyes. If this does happen, rinse with water.

Do not use other nasal medications during treatment with mupirocin nasal unless your doctor tells you to.

What other drugs will affect mupirocin nasal (Bactroban Nasal)?

There may be other drugs that can interact with mupirocin nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about mupirocin nasal.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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  • Bactroban Nasal

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