Drugs Details

Drugs Info of Acthrel
Drugs Details
  • Drugs Type  : FDA
  • Date : 26th Dec 2014 10:46 pm
  • Brand Name : Acthrel
  • Generic Name : (corticorelin ovine triflutate) for Injection
Descriptions

ACTHREL® (corticorelin ovine triflutate for injection) is a sterile, nonpyrogenic, lyophilized white cake powder, containing corticorelin ovine triflutate, a trifluoroacetate salt of a synthetic peptide that is used for the determination of pituitary corticotroph responsiveness. Corticorelin ovine has an amino acid sequence identical to ovine corticotropin-releasing hormone (oCRH). Corticorelin ovine is an analogue of the naturally occurring human CRH (hCRH) peptide. Both peptides are potent stimulators of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. ACTH stimulates cortisol production from the adrenal cortex. The structural formula for corticorelin ovine triflutate is described below:

Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-
Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2XCF3COOH

whereas X=4 - 8.

The empirical formula of corticorelin ovine is C205H339N59O63S with a molecular weight of 4670.35 Daltons.

ACTHREL® (corticorelin ovine triflutate for injection) for injection is available in vials containing 100 mcg corticorelin ovine (as the trifluoroacetate), 0.88 mg ascorbic acid, 10 mg lactose, and 26 mg cysteine hydrochloride monohydrate. Trace amounts of chloride ion may be present from the manufacturing process. The preparation is intended for intravenous administration.

What are the possible side effects of corticorelin ovine trifluate (Acthrel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you feel like you might pass out, or if you have:

  • a fast heart rate;
  • a tight feeling in your chest; or
  • if you feel like you need to take deep breaths.

Less serious side effects may include warmth, redness, or tingly feeling in your face, neck, or chest.

This is not a complete list of side effects and others may occur. Tell your...

Read All Potential Side Effects and See Pictures of Acthrel »


This monograph has been modified to include the generic and brand name in many instances.

Indications

ACTHREL® (corticorelin ovine triflutate for injection) is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.

Differential Diagnosis: There are two forms of Cushing's syndrome:

  1. ACTH-dependent (83%), in which hypercortisolism is due either to pituitary hypersecretion of ACTH (Cushing's disease) resulting from an adenoma (40%, usually microadenomas) or nonadenomatous hyperplasia, possibly of hypothalamic origin (28%), or to hypercortisolism that is secondary to ectopic secretion of ACTH (15%) and,
  2. ACTH-independent (17%), in which hypercortisolism is due to autonomous cortisol secretion by an adrenal tumor (9% adenomas, 8% carcinomas).

After the establishment of hypercortisolism consistent with the presence of Cushing's syndrome, and following the elimination of autonomous adrenal hyperfunction as its cause, the corticorelin test is used to aid in establishing the source of excessive ACTH secretion.

The corticorelin stimulation test helps to differentiate between the etiologies of ACTH-dependent hypercortisolism as follows:

  1. High basal plasma ACTH plus high basal plasma cortisol (20 - 40 mcg/dL). ACTHREL® (corticorelin ovine triflutate for injection) injection (1 mcg/kg) results in:
    1. Increased plasma ACTH levels
    2. Increased plasma cortisol levels
      Diagnosis: Cushing's disease (ACTH of pituitary origin)
  2. High basal plasma ACTH (may be very high) plus high basal plasma cortisol (20 - 40 mcg/dL).
    ACTHREL® (corticorelin ovine triflutate for injection) injection (1 mcg/kg) results in:
    1. Little or no response of plasma ACTH levels
    2. Little or no response of plasma cortisol levels
      Diagnosis: Ectopic ACTH syndrome

Test Methodology: To evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion, a corticorelin test procedure requires a minimum of five blood samples.

Procedure

  1. Venous blood samples should be drawn 15 minutes before and immediately prior to ACTHREL® (corticorelin ovine triflutate for injection) administration. The ACTH baseline is obtained by averaging the values of the two samples.
  2. Administer ACTHREL® (corticorelin ovine triflutate for injection) as an intravenous infusion over a 30- to 60- second interval at a dose of 1 mcg/kg body weight. Higher doses are not recommended (see PRECAUTIONS and ADVERSE REACTIONS).
  3. Draw venous blood samples at 15, 30, and 60 minutes after administration.
  4. Blood samples should be handled as recommended by the laboratory that will determine their ACTH content. It is extremely important to recognize that the reliability of the ACTHREL® (corticorelin ovine triflutate for injection) test is directly related to the inter-assay and intra-assay variability of the laboratory performing the assay.

Cortisol determinations may be performed on the same blood samples for the same time points as outlined above. The blood sample handling precautions noted for ACTH should be followed for cortisol.

Interpretation of Test Results: The interpretation of the ACTH and cortisol responses following ACTHREL® (corticorelin ovine triflutate for injection) administration requires a knowledge of the clinical status of the individual patient, understanding of hypothalamic-pituitary-adrenal physiology, and familiarity with the normal hormonal ranges and the standards used by the laboratory that performs the ACTH and cortisol assays.

Cushing's Disease: The results of challenge with corticorelin injection have been reported in approximately 300 patients with Cushing's disease. Although the ACTH and cortisol responses were variable, a hyper-response to corticorelin was seen in a majority of patients, despite high basal cortisol levels. This response pattern indicates an impairment of the negative feedback of cortisol on the pituitary. Patients with pituitary-dependent Cushing's disease tested with corticorelin do not show the negative correlation between basal and stimulated levels of ACTH and cortisol that is found in normal subjects. A positive correlation between basal ACTH levels and maximum ACTH increments after corticorelin administration has been found in Cushing's disease patients.

Ectopic ACTH Secretion: Patients with Cushing's syndrome due to ectopic ACTH secretion (N=32) were found to have very high basal levels of ACTH and cortisol, which were not further stimulated by corticorelin. However, there have been rare instances of patients with ectopic sources of ACTH that have responded to the corticorelin test.

SUMMARY OF ACTH RESPONSES IN PATIENTS WITH HIGH BASAL CORTISOL

  High ACTH Response Low ACTH Response
High Basal ACTH Cushing's Disease Ectopic ACTH Secretion

Cushing's Disease ACTH responses
(mean of 181 patients)
Basal ACTH 63 ± 72 pg/mL (mean ± SD)
Peak ACTH 189 ± 262 pg/mL (mean ± SD)
Mean of individual change from baseline + 227%

Ectopic ACTH secretion responses
(mean for 31 patients)
Basal ACTH 266 ± 464 pg/mL (mean ± SD)
Peak ACTH 276 ± 466 pg/mL (mean ± SD)
Mean of individual change from baseline + 15%

False negative responses to the corticorelin test in Cushing's disease patients occur approximately 5 to 10% of the time, which may lead the clinician to an incorrect diagnosis of ectopic production of ACTH at that frequency. (See INDICATIONS AND USAGE, Differential Diagnosis)

Dosage Administration

Dosage

A single intravenous dose of ACTHREL® (corticorelin ovine triflutate for injection) at 1 mcg/kg is recommended for the testing of pituitary corticotrophin function. A dose of 1 mcg/kg is the lowest dose that produces maximal cortisol responses and significant (though apparently sub-maximal) ACTH responses. Doses above 1 mcg/kg are not recommended. (See PRECAUTIONS and ADVERSE REACTIONS)

At a dose of 1 mcg/kg, the ACTH and cortisol responses to ACTHREL® (corticorelin ovine triflutate for injection) are prolonged and remain elevated for up to 2 hours. The maximum increment in plasma ACTH occurs between 15 and 60 minutes after ACTHREL® (corticorelin ovine triflutate for injection) administration, whereas the maximum increment in plasma cortisol occurs between 30 and 120 minutes. In a clinical study of 30 normal healthy men, the peak plasma ACTH and cortisol responses to ACTHREL® (corticorelin ovine triflutate for injection) administration in the early afternoon occurred at 42 ± 29 minutes and 65 ± 26 minutes (average ± SD), respectively. If a repeated evaluation using the corticorelin stimulation test with ACTHREL® (corticorelin ovine triflutate for injection) is needed, it is recommended that the repeat test be carried out at the same time of day as the original test because there are differences in basal levels and peak response levels following a.m. or p.m. administration to normal humans.

Administration

ACTHREL® (corticorelin ovine triflutate for injection) is to be reconstituted aseptically with 2 mL of Sodium Chloride injection, USP (0.9% sodium chloride), at the time of use by injecting 2 mL of the saline diluent into the lyophilized drug product cake. To avoid bubble formation, DO NOT SHAKE the vial; instead, roll the vial to dissolve the product. The sterile solution containing 50 mcg corticorelin/mL is then ready for injection by the intravenous route. The dosage to be administered is determined by the patient's weight (1 mcg corticorelin/kg). Some of the adverse effects can be reduced by administering the drug as an infusion over 30 seconds instead of as a bolus injection.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

How Supplied

ACTHREL® (corticorelin ovine triflutate for injection) is supplied as a sterile, monpyrogenic, lyophilized, white cake containing 100 mcg corticorelin ovine (as the trifluoroacetate), 0.88 mg ascorbic acid, 10 mg lactose, and 26 mg cysteine hydrochloride monohydrate. Trace amounts of chloride ion may be present from the manufacturing process. The package provides a single-dose, rubber-capped, 5 mL, brown-glass vial (NDC 55566-0302-1) containing 100 mcg corticorelin ovine (as the trifluoroacetate). ACTHREL® (corticorelin ovine triflutate for injection) is stable in the lyophilized form when stored refrigerated at 2°C to 8°C (36°F to 46°F) and protected from light. The reconstituted solution is stable up to 8 hours under refrigerated conditions. Discard unused reconstituted solution.

Manufactured for: Ferring Pharmaceuticals, Inc., Tarrytown, New York 10591. By: Ben Venue Laboratories, Inc., Bedford, OH 44146. FDA revision date: 7/16/2002


This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Adverse effects reported with 1 mcg/kg or 100 mcg/patient include flushing of the face, neck, and upper chest (16%; 45/276), beginning almost immediately and lasting 3 to 5 minutes. Recipients have also reported an urge to take a deep breath (6%; 3/49), which occurs with a timing similar to, but less frequently than, that of flushing. Higher doses ( > =3mcg/kg) are associated with more prolonged flushing, tachycardia, hypotension, dyspnea, and “chest compression” or tightness. In addition, at doses of > =5 mcg/kg, significant increases in heart rate and decreases in blood pressure were observed. The cardiovascular effects occurred 2-3 minutes after injection and lasted for 30-60 minutes. The facial flushing was more prolonged, lasting up to 4 hours in some subjects. All signs and symptoms could be reduced by administering the drug as a 30-second infusion instead of by bolus injection.

Total doses of up to 200 mcg of corticorelin were administered as a bolus injection to 60 men and women, including both healthy normal subjects and patients with endocrine disorders. In most cases, only minor adverse effects, such as transient flushing and feelings of dyspnea, were noted. However, a few patients with disorders of the pituitary-adrenal axis had major symptoms. One patient had a precipitous fall in blood pressure and pulse rate and developed asystole, which required resuscitation. In two patients with Cushing's disease and in one with secondary adrenal insufficiency, an Òabsence-likeÓ loss of consciousness occurred, which started within a few seconds after injection of corticorelin and lasted from 10 seconds to 5 minutes. This was accompanied by a slight fall in blood pressure. One patient with a well documented seizure diathesis experienced a grand mal epileptic seizure following ACTHREL® (corticorelin ovine triflutate for injection) administration. The patient had discontinued anti-convulsant therapy the day of the procedure. (See PRECAUTIONS and DRUG INTERACTIONS)

Read the Acthrel (corticorelin ovine triflutate for injection) Side Effects Center for a complete guide to possible side effects

Interactions

The plasma ACTH response to corticorelin injection is inhibited or blunted in normal subjects pretreated with dexamethasone. The use of a heparin solution to maintain i.v. cannula patency during the corticorelin test is not recommended. A possible interaction between corticorelin and heparin may have been responsible for a major hypotensive reaction that occurred after corticorelin administration. (See ADVERSE REACTIONS)

Read the Acthrel Drug Interactions Center for a complete guide to possible interactions

Learn More »


This monograph has been modified to include the generic and brand name in many instances.

Warnings

No information provided.

Precautions

General

The severity of adverse effects to a corticorelin injection appear to be dose-dependent. Dosages above 1 mcg/kg are not recommended. While few adverse effects have been observed at the 1 mcg/kg or 100 mcg dose, higher doses have been associated with transient tachycardia, decreased blood pressure, loss of consciousness, and asystole (see ADVERSE REACTIONS). These symptoms can be substantially reduced by administering the drug as a 30-second intravenous infusion instead of a bolus injection. At a dose of 200 mcg corticorelin, 4 of 60 volunteers and patients with disturbances of the hypothalamic-pituitary-adrenal (HPA) axis were reported to have had decreased blood pressures. One patient had a severe hypotensive reaction with asystole. Three other patients had an “absence-like” loss of consciousness lasting approximately 5 minutes. In subsequent investigations by the same researchers over a 3-year period using 100 mcg of corticorelin, one patient in approximately 150 to 200 experienced a severe drop in blood pressure and loss of sinus rhythm after receiving 55 mcg of corticorelin, which may have been due to interaction with heparin. (See DRUG INTERACTIONS)

Carcinogenesis, Mutagenesis, Impairment of Fertility

Animal studies have not been conducted with corticorelin to evaluate carcinogenic potential, mutagenicity, or effect on fertility.

Pregnancy (Pregnancy Category C)

Animal reproduction studies have not been conducted with corticorelin. It is also not known whether corticorelin can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. ACTHREL® (corticorelin ovine triflutate for injection) should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether corticorelin is secreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when ACTHREL® (corticorelin ovine triflutate for injection) is administered to a nursing woman.

Pediatric Use

Only a few tests have been performed on children. Dosages were 1 mcg/kg body weight. Patient studies have involved only children with multiple hypothalamic and/or pituitary hormone deficiencies, or tumors. Only two studies with normal pediatric subjects have been conducted. No differences in response to the corticorelin test have been reported in the children studied.


This monograph has been modified to include the generic and brand name in many instances.

OverDose

Symptoms of overdose include severe facial flushing, cardiovascular changes, and dyspnea. In the event of toxic overdose (see ADVERSE REACTIONS), adverse effects should be treated symptomatically.

ContrainDications

No information provided.


This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

Pharmacodynamics

In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol. In addition, intravenous administration of corticorelin to normal subjects causes a concomitant and prolonged release of the related proopiomelanocortin peptides β- and ¥-lipotropins (β-and ¥-LPH) and β-endorphin (β-END). A number of dose-response studies have been performed on normal subjects using a range of corticorelin doses. In one study, doses of corticorelin ranging from 0.001 to 30 mcg/kg body weight were administered to 29 healthy volunteers. Blood samples were taken over a 2-hour period for determination of plasma ACTH and cortisol concentrations. There was a direct dose-dependent relationship that was more pronounced for ACTH than for cortisol. The threshold dose was 0.03 mcg/kg, the half-maximal dose was 0.3-1.0 mcg/kg and the maximally effective dose was 3-10 mcg/kg.

Plasma ACTH levels in normal subjects increased 2 minutes after injection of corticorelin doses of > =0.3 mcg/kg and reached peak levels after 10-15 minutes. Plasma cortisol levels increased within 10 minutes and reached peak levels at 30 to 60 minutes. As the dose of corticorelin was increased, the rises in plasma ACTH and cortisol were more sustained, showing a biphasic response with a second lower peak at 2-3 hours after injection. Similar results were found in another study using 0.3, 3.0, and 30 mcg/kg doses. The duration of mean plasma ACTH increase after injection of 0.3, 3.0, and 30 mcg/kg was 4, 7, and 8 hours, respectively. The effect on plasma cortisol was similar, but more prolonged. Because there are differences in basal levels and peak response levels following a.m. or p.m. administration, it is recommended that subsequent evaluations in the same patient using the corticorelin stimulation test be carried out at the same time of day as the original evaluation.

Baseline ACTH and cortisol levels are usually higher in the morning. Pooled ACTH values from normal unstressed subjects (n=119) were 25 ± 7 pg/mL in the a.m. and 10 ± 3 in the p.m.; similar pooled cortisol values (n=170) were 11 ± 3 mcg/dL in the a.m. and 4 ± 2 mcg/dL in the p.m. The normal unstressed person has about seven to ten secretory episodes of ACTH each day. Most of them occur in the early morning hours and are responsible for the morning plasma cortisol surge. The following figure shows the daily circadian rhythm of ACTH and cortisol secretions in a normal unstressed person. Insulin, plasma renin activity, prolactin, and growth hormone release are not affected by corticorelin administration in humans.

 

Daily circadian rhythm of ACTH and cortisol secretions in a normal unstressed person - Illustration

Continuous 24-hour infusion of corticorelin (0.5, 1.0, and 3.0 mcg/kg/hr) increased plasma ACTH concentrations to a plateau of 15-20 pg/mL by the third hour and urinary-free cortisol reaches 173 ± 43 mcg/dL by 24 hours, comparable to those levels observed in patients with major depression, but less than levels noted in Cushing's disease. Continuous infusion did not abolish the circadian rhythm of plasma ACTH and cortisol, but did appear to desensitize the corticotroph. Intermittent doses of corticorelin (25 mcg every 4 hours for 72 hours), however, continued to elicit the expected ACTH and cortisol responses.

Intravenous administration of 1 mcg/kg corticorelin in combination with 10 pressor units intramuscular vasopressin had a synergistic effect on ACTH and a less marked synergistic effect on cortisol secretion.

The basal and peak response levels of ACTH and cortisol to a 1 mcg/kg or 100 mcg dose of corticorelin administered to normal volunteers in the morning and the evening are given below. These values were obtained by combining the results from 9 clinical trials conducted in the a.m. and 4 clinical trials conducted in the p.m.

The following table is to be used only as a general guide.

Basal Concentrations and Peak Responses of ACTH and Cortisol in Normal Subjects after 1 mcg/kg or 100 mcg of ACTHREL® (corticorelin ovine triflutate for injection) (corticorelin ovine triflutate for injection)

Time of Day No. of Subjects ACTH Concentration mean (range) pg/mL Cortisol Concentration mean (range) mcg/dL
Basal Peak Basal Peak
a.m. 143 28 (16-65) 68 (39-114) 11 (8-13) 21 (17-25)
p.m. 70 9 (8-13) 30 (25-42) 4 (2-6) 16 (15-18)

Pharmacokinetics

Following a single intravenous injection of 1 mcg/kg of corticorelin to normal men, the disappearance of immunoreactive corticorelin (IR-corticorelin) from plasma follows a biexponential decay curve. Plasma half-lives for IR-corticorelin are 11.6 ± 1.5 minutes (mean ± SE) for the fast component and 73 ± 8 minutes for the slow component. The mean volume of distribution for IR-corticorelin is 6.2 ± 0.5 L with an approximate metabolic clearance rate of 95 ± 11 L/m²/day. Graded intravenous doses of corticorelin (0.01, 0.03, 0.1, 0.3, 1, 3, 10, 30 mcg/kg) produced a linear increase in plasma IR-corticorelin. Corticorelin does not appear to be bound specifically by a circulating plasma protein.


This monograph has been modified to include the generic and brand name in many instances.

Patient Information

No information provided. Please refer to the PRECAUTIONS section.


This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

No Information Available!

Consumer Overview Side Effect

No Information Available!

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

Brand Names: Acthrel

Generic Name: corticorelin ovine triflutate (Pronunciation: KOR ti koe REL in OH vine TRYE floo ate)

  • What is corticorelin ovine trifluate (Acthrel)?
  • What are the possible side effects of corticorelin ovine trifluate (Acthrel)?
  • What is the most important information I should know about corticorelin ovine trifluate (Acthrel)?
  • What should I discuss with my health care provider before receiving corticorelin ovine trifluate (Acthrel)?
  • How is corticorelin ovine trifluate given (Acthrel)?
  • What happens if I miss a dose (Acthrel)?
  • What happens if I overdose (Acthrel)?
  • What should I avoid after receiving corticorelin ovine trifluate (Acthrel)?
  • What other drugs will affect corticorelin ovine trifluate (Acthrel)?
  • Where can I get more information?

What is corticorelin ovine trifluate (Acthrel)?

Corticorelin ovine trifluate is a man-made form of a hormone that occurs naturally in the body.

Corticorelin ovine trifluate is used as part of a medical test in people with Cushing's syndrome. Cushing syndrome is an endocrine disorder caused by high levels of cortisol (a steroid hormone produced by the adrenal gland).

This medication is also used to help your doctor determine why your body is producing too much of its own cortisol.

Corticorelin ovine trifluate may also be used for purposes not listed in this medication guide.

What are the possible side effects of corticorelin ovine trifluate (Acthrel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you feel like you might pass out, or if you have:

  • a fast heart rate;
  • a tight feeling in your chest; or
  • if you feel like you need to take deep breaths.

Less serious side effects may include warmth, redness, or tingly feeling in your face, neck, or chest.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Acthrel (corticorelin ovine triflutate for injection) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about corticorelin ovine trifluate (Acthrel)?

Tell your doctor about any allergies or medical conditions you have.

Tell your doctor if you have recently used dexamethasone (Decadron, Dexone, Hexadrol). Dexamethasone can affect the results of your corticorelin test.

During the corticorelin test, your caregivers will need to draw at least 5 blood samples from you. This will help your doctor determine more about your condition.

The timing of your blood tests before and after the injection is important in assuring the most accurate results from a corticorelin test. Plan to stay in the care of your healthcare providers for at least 1 hour after your injection.

Tell your caregivers at once if you feel like you might pass out, or if you have a fast heart rate, a tight feeling in your chest, or if you feel like you need to take deep breaths.

Side Effects Centers
  • Acthrel

Patient Detailed How Take

What should I discuss with my health care provider before receiving corticorelin ovine trifluate (Acthrel)?

Tell your doctor about any allergies or medical conditions you have.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Before you receive corticorelin ovine trifluate, tell your doctor if you are pregnant.

It is not known whether corticorelin ovine trifluate passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is corticorelin ovine trifluate given (Acthrel)?

You will receive corticorelin ovine trifluate in a clinic or hospital setting. The medication is given as a single injection through a needle placed into a vein. Your blood will be tested before and after you receive the injection.

During the corticorelin test, your caregivers will need to draw at least 5 blood samples from you. This will help your doctor determine more about your condition.

In most cases, the blood is tested 15 minutes before and then right before you receive the injection. These tests will give your doctor two "baseline" measurements.

After you receive corticorelin ovine trifluate, your blood will be drawn again at 15 minutes, 30 minutes, and 60 minutes after the injection. This will help your doctor determine more about your condition.

Side Effects Centers
  • Acthrel

Patient Detailed Avoid Taking

What happens if I miss a dose (Acthrel)?

Since this medication is usually given as a single dose, you are not likely to be on a dosing schedule.

The timing of your blood tests before and after the injection is important in assuring the most accurate results from a corticorelin test. Plan to stay in the care of your healthcare providers for at least 1 hour after your injection.

What happens if I overdose (Acthrel)?

Seek emergency medical attention if you think you have received too much of this medicine.

Overdose symptoms may include chest tightness, fast heart rate, trouble breathing, or severe redness or warmth in your face.

What should I avoid after receiving corticorelin ovine trifluate (Acthrel)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity after you receive this medication.

What other drugs will affect corticorelin ovine trifluate (Acthrel)?

Tell your doctor if you have recently used dexamethasone (Decadron, Dexone, Hexadrol). Dexamethasone can affect the results of your corticorelin test.

There may be other drugs that can interact with corticorelin ovine trifluate. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about corticorelin ovine trifluate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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