Drugs Details

Drugs Info of BAL In Oil
Drugs Details
  • Drugs Type  : FDA
  • Date : 26th Dec 2014 11:24 pm
  • Brand Name : BAL In Oil
  • Generic Name : dimercaprol (Pronunciation: DYE mer KAP rol)
Descriptions

BAL (2, 3-dimercapto-1-propanol) 10%, Benzyl Benzoate 20%, in Peanut Oil

C3H8OS2                Molecular Weight 124.22

Dimercaprol Injection USP is a colorless or almost colorless liquid chelating agent having a disagreeable, mercaptan-like odor. Each 1 mL sterile BAL in Oil (Dimercaprol Injection USP) contains: 100 mg Dimercaprol in 200 mg Benzyl Benzoate and 700 mg Peanut Oil.

What are the possible side effects of dimercaprol (BAL In Oil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • fast heart rate, feeling anxious or restless;
  • pain or tightness in your throat, chest, or hands;
  • burning sensation of your throat, mouth, or lips; or
  • burning sensation in your penis.

Less serious side effects include:

  • nausea, vomiting, stomach pain;
  • numbness or tingling...

Read All Potential Side Effects and See Pictures of Bal in Oil Ampules »

This monograph has been modified to include the generic and brand name in many instances.

Indications

BAL in Oil (Dimercaprol Injection USP) is indicated in the treatment of arsenic, gold and mercury poisoning. It is indicated in acute lead poisoning when used concomitantly with Edetate Calcium Disodium Injection USP.

Dimercaprol Injection USP is effective for use in acute poisoning by mercury salts if therapy is begun within one or two hours following ingestion. It is not very effective for chronic mercury poisoning.

Dimercaprol Injection USP is of questionable value in poisoning caused by other heavy metals such as antimony and bismuth. It should not be used in iron, cadmium, or selenium poisoning because the resulting dimercaprol-metal complexes are more toxic than the metal alone, especially to the kidneys.

Dosage Administration

By deep intramuscular injection only. For mild arsenic or gold poisoning, 2.5 mg/kg of body weight four times daily for two days, two times on the third day, and once daily thereafter for ten days; for severe arsenic or gold poisoning, 3 mg/kg every four hours for two-days, four times on the third day, then twice daily thereafter for ten days. For mercury poisoning, 5 mg/kg initially, followed by 2.5 mg/kg one or two times daily for ten days. For acute lead encephalopathy, 4 mg/kg body weight is given alone in the first dose and thereafter at four-hour intervals in combination with Edetate Calcium Disodium Injection USP administered at a separate site. For less severe poisoning the dose can be reduced to 3 mg/kg after the first dose. Treatment is maintained for two to seven days depending on clinical response. Successful treatment depends on beginning injections at the earliest possible moment and on the use of adequate amounts at frequent intervals. Other supportive measures should always be used in conjunction with BAL in Oil (Dimercaprol Injection USP) therapy.

BAL in Oil should be inspected visually for particulate matter and discoloration prior to administration.

How Supplied

3 mL (100 mg/mL) ampules, box of 10 (NDC 11098-526-03).

STORAGE: Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature.]

Manufactured by: Decatur, IL 62522
Rev. 10/06
FDA rev date: 4/18/2007

This monograph has been modified to include the generic and brand name in many instances.

Side Effects

One of the most consistent responses to Dimercaprol Injection USP is a rise in blood pressure accompanied by tachycardia. This rise is roughly proportional to the dose administered. Doses larger than those recommended may cause other transitory signs and symptoms in approximate order of frequency as follows: (1) nausea and, in some instance, vomiting; (2) headache; (3) a burning sensation in the lips, mouth and throat; (4) a feeling of constriction, even pain, in the throat, chest, or hands; (5) conjunctivitis, lacrimation, blepharal spasm, rhinorrhea, and salivation; (6) tingling of the hands; (7) a burning sensation in the penis; (8) sweating of the forehead, hands and other areas; (9) abdominal pain; and (10) occasional appearance of painful sterile abscesses. Many of the above symptoms are accompanied by a feeling of anxiety, weakness, and unrest and often are relieved by administration of antihistamine.

Drug Abuse And Dependence

Dimercaprol Injection USP is not a controlled substance listed in any other Drug Enforcement Administration schedules. Its use is not known to lead to dependence or abuse.

Read the Bal in Oil Ampules (dimercarprol injection) Side Effects Center for a complete guide to possible side effects

Interactions

No information provided.

This monograph has been modified to include the generic and brand name in many instances.

Warnings

There may be local pain at the site of the injection. A reaction apparently peculiar to children is fever which may persist during therapy. It occurs in approximately 30% of children. A transient reduction of the percentage of polymorphonuclear leukocytes may also be observed.

Precautions

Because the dimercaprol-metal complex breaks down easily in an acid medium, production of an alkaline urine affords protection to the kidney during therapy. Medicinal iron should not be administered to patients under therapy with BAL in Oil (Dimercaprol Injection USP).

BAL in Oil Ampules (dimercarprol injection) is formulated with peanut oil. Peanut oil may cause allergic reactions in some individuals. Physicians should use caution in prescribing BAL in Oil Ampules (dimercarprol injection) for peanut-sensitive patients. Medication and equipment necessary to treat allergic reactions should be available if the product is administered to peanut-allergic patients.

Pregnancy Category C

Animal reproduction studies have not been conducted with BAL in Oil. It is also not known whether BAL in Oil can cause fetal harm when administered to a pregnant woman, or can affect reproduction capacity. BAL in Oil should be given to a pregnant woman only if clearly needed.

It is not known whether this drug is excreted in human milk. However, because many drugs are excreted in human milk, caution should be exercised when BAL in Oil is administered to a nursing woman.

This monograph has been modified to include the generic and brand name in many instances.

OverDose

Dosage exceeding 5 mg/kg will usually be followed by vomiting, convulsions and stupor, beginning within 30 minutes and subsiding within 6 hours following injection.

ContrainDications

BAL in Oil (Dimercaprol Injection USP) is contraindicated in most instances of hepatic insufficiency with the exception of postarsenical jaundice. The drug should be discontinued or used only with extreme caution if acute renal insufficiency develops during therapy.

AMER. HOSP. FORM. SERV., 64:00, Amer. Soc. Hosp. Pharm., 1977.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

The sulfhydryl groups of dimercaprol form complexes with certain heavy metals thus preventing or reversing the metallic binding of sulfhydryl-containing enzymes. The complex is excreted. The sustained presence of dimercaprol promotes continued excretion of the metallic poisons - arsenic, gold and mercury. It is also used in combination with Edetate Calcium Disodium Injection USP to promote the excretion of lead.

Animal Toxicology

The intramuscular LD50 in rats is approximately 105 mg/kg; intraperitoneally 140 mg/kg. The intraperitoneal LD80 in mice is approximately 125 mg/kg.

JR. PHARM. EXPER. THER. 87, Supplement Aug. 1946.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

No Information Available!

Consumer Overview Side Effect

No Information Available!

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

Brand Names: BAL In Oil

Generic Name: dimercaprol (Pronunciation: DYE mer KAP rol)

  • What is dimercaprol (Bal in Oil Ampules)?
  • What are the possible side effects of dimercaprol (Bal in Oil Ampules)?
  • What is the most important information I should know about dimercaprol (Bal in Oil Ampules)?
  • What should I discuss with my health care provider before receiving dimercaprol (Bal in Oil Ampules)?
  • How should I take dimercaprol (Bal in Oil Ampules)?
  • What happens if I miss a dose (Bal in Oil Ampules)?
  • What happens if I overdose (Bal in Oil Ampules)?
  • What should I avoid after receiving dimercaprol (Bal in Oil Ampules)?
  • What other drugs will affect dimercaprol (Bal in Oil Ampules)?
  • Where can I get more information?

What is dimercaprol (Bal in Oil Ampules)?

Dimercaprol is a chelating (KEE-late-ing) agent. A chelating agent is capable of removing a heavy metal, such as lead or mercury, from the blood.

Dimercaprol is used to treat poisoning with arsenic, gold, or mercury. It is also used together with another medication called edetate disodium (EDTA) to treat lead poisoning.

Dimercaprol may also be used for other purposes not listed in this medication guide.

What are the possible side effects of dimercaprol (Bal in Oil Ampules)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • fast heart rate, feeling anxious or restless;
  • pain or tightness in your throat, chest, or hands;
  • burning sensation of your throat, mouth, or lips; or
  • burning sensation in your penis.

Less serious side effects include:

  • nausea, vomiting, stomach pain;
  • numbness or tingling (especially around your mouth);
  • headache;
  • eye redness, swelling, or watering;
  • twitching of your eyelid;
  • runny nose;
  • increased sweating;
  • mild fever; or
  • pain, redness, or swelling where the needle is placed.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Bal in Oil Ampules (dimercarprol injection) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about dimercaprol (Bal in Oil Ampules)?

If possible, before you receive dimercaprol, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

Dimercaprol may contain peanut oil. Tell your caregivers if you have a peanut allergy.

In a poisoning situation, it may not be possible before you are treated to tell your caregivers about any health conditions you have or if you are pregnant or breast-feeding. However, make sure any doctor caring for you afterward knows that you have received this medication.

Dimercaprol is most effective when used within 1 or 2 hours after a poisoning. It may not be as effective in treating long-term poisoning.

Side Effects Centers
  • Bal in Oil Ampules

Patient Detailed How Take

What should I discuss with my health care provider before receiving dimercaprol (Bal in Oil Ampules)?

If possible, before you receive dimercaprol, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

If you have any of these conditions, you may not be able to receive dimercaprol, or you may need a dose or special tests to safely receive this medication.

Dimercaprol may contain peanut oil. Tell your caregivers if you have a peanut allergy.

FDA pregnancy category C. This medication may be harmful to an unborn baby and is not recommended in pregnant women unless clearly needed.

It is not known whether dimercaprol passes into breast milk or if it could harm a nursing baby.

In an emergency situation, it may not be possible before you are treated with dimercaprol to tell your caregivers if you are pregnant or breast-feeding. However, make sure any doctor caring for your pregnancy or your baby knows that you have received this medication.

How should I take dimercaprol (Bal in Oil Ampules)?

Dimercaprol is given as an injection into a muscle. You will receive this injection in a hospital or emergency setting.

Dimercaprol may be given for several days, depending on the type of poisoning being treated.

Dimercaprol is most effective when used within 1 or 2 hours after a poisoning. It may not be as effective in treating long-term poisoning.

Side Effects Centers
  • Bal in Oil Ampules

Patient Detailed Avoid Taking

What happens if I miss a dose (Bal in Oil Ampules)?

Since dimercaprol is given as needed by a healthcare professional, it is not likely that you will miss a dose.

What happens if I overdose (Bal in Oil Ampules)?

Tell your caregivers right away if you think you have received too much of this medicine.

Overdose symptoms may include nausea, vomiting, extreme drowsiness, or seizure (convulsions).

What should I avoid after receiving dimercaprol (Bal in Oil Ampules)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity after you are treated with dimercaprol.

What other drugs will affect dimercaprol (Bal in Oil Ampules)?

There may be other drugs that can interact with dimercaprol. Tell your doctor about all prescription and over-the-counter medications you have recently used, including vitamins, minerals, herbal products, and drugs prescribed by other doctors.

Where can I get more information?

Your doctor or pharmacist can provide more information about dimercaprol.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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