Drugs Details

Drugs Info of A/T/S, Akne-Mycin, Emcin Clear, Emgel, Eryderm, Erygel, Erymax, Romycin, Theramycin Z
Drugs Details
  • Drugs Type  : FDA
  • Date : 29th Jan 2015 02:32 am
  • Brand Name : A/T/S, Akne-Mycin, Emcin Clear, Emgel, Eryderm, Erygel, Erymax, Romycin, Theramycin Z
  • Generic Name : erythromycin topical (Pronunciation: ee RITH roe MYE sin)
Descriptions

EMGEL (erythromycin) Topical Gel contains erythromycin. Erythromycin is amacrolide antibiotic obtained from cultures of Streptomyces erythreus.

Erythromycin has the empirical formula C 37 67 NO 13 and a molecular weight of 733.94. It has the following structural formula:

emgel

EMGEL Topical Gel contains erythromycin, USP 2% (20 mg/g) with SD 40-2alcohol 77%, propylene glycol, and hydroxypropyl cellulose.

 

What are the possible side effects of erythromycin topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using erythromycin topical and call your doctor at once if you have any of these serious side effects:

  • severe burning, stinging, or redness;
  • oozing or other signs of skin infection;
  • worsening of your skin condition; or
  • diarrhea that is watery or bloody.

Less serious side effects may include:

  • mild skin irritation or tenderness;
  • dry or oily...

Read All Potential Side Effects and See Pictures of Emgel »

What are the precautions when taking erythromycin (Emgel)?

Before using erythromycin, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (e.g., azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Emgel »

 

This monograph has been modified to include the generic and brand name in many instances.

Indications

EMGEL (erythromycin) Topical Gel is indicated for the topical treatment ofacne vulgaris.

Dosage Administration

Apply sparingly as a thin layer to affected area(s) twice a day, in the morning and the evening, after the skin has been thoroughly washed with soap and water and patted dry. The hands should be washed after application. If there has been no improvement after 6 to 8 weeks, or if the condition becomes worse, treatment should be discontinued, and the physician should be reconsulted. Spread the medication lightly rather than rubbing it in.

How Supplied

ERYGEL® (Erythromycin Topical Gel USP) 2% is supplied in plastic tubes in the following sizes:

30g - NDC 0259-4312-30 and 60 g - NDC 0259-4312-60.

Note: FLAMMABLE. Keep away from heat and flame. Store and dispense in original container. Keep tube tightly closed. Store between 15° and 25°C (59° and 77°F).

Manufactured for: Merz Pharmaceuticals, Greensboro, NC 27410 
70-2057-00 
Rev 10/01

This monograph has been modified to include the generic and brand name in many instances.

Side Effects

The most common adverse reaction reported with EMGEL (erythromycin)Topical Gel was burning. The following have been reported occasionally: peeling, dryness, itching, erythema, and oiliness. Irritation of the eyes and tenderness of the skin have also been reported with the topical use oferythromycin. A generalized urticarial reaction, which was possibly related to the use of erythromycin and required systemic steroid therapy, has been reported.

Read the Emgel (erythromycin) Side Effects Center for a complete guide to possible side effects

Learn More »
 
 
 

Interactions

No Information Provided.

This monograph has been modified to include the generic and brand name in many instances.

Warnings

Pseudomembranous colitis has been reported with nearly allantibacterial agents, including erythromycin, and may range in severity from mild to life-threatening. Therefore, it is important to consider thisdiagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents.

Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced byClostridium difficile is one primary cause of "antibiotic-associated colitis".

After the diagnosis of pseudomembranous colitis has been established,therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation and treatment with an antibacterial drug clinically effective against C. difficile colitis.

Precautions

General:   For topical use only; not for ophthalmic use. Concomitant topicalacne therapy should be used with caution since a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating, or abrasive agents.

Avoid contact with eyes and all mucous membranes. The use of antibioticagents may be associated with the overgrowth of antibiotic-resistant organisms. If this occurs, discontinue use and take appropriate measures.

Carcinogenesis, Mutagenesis, Impairment of Fertility: No animal studies have been performed to evaluate carcinogenic and mutagenic potential or effects on fertility of topical erythromycin. However, long-term (2-year) oral studies in rats with erythromycin ethylsuccinate and erythromycin base did not provide evidence of tumorigenicity. There was no apparent effect on male or female fertility in rats fed erythromycin (base) at levels up to 0.25% of diet.

Pregnancy: Teratogenic effects: Pregnancy Category B: There was no evidence of teratogenicity or any other adverse effect on reproduction in female rats fed erythromycin base (up to 0.25% of diet) prior to and during mating, during gestation and through weaning of two successive litters. There are, however, no adequate and well-controlled studies in pregnantwomen. Because animal reproduction studies are not always predictive of human response, this drug should be used in pregnancy only if clearly needed. Erythromycin has been reported to cross the placental barrier in humans, but fetal plasma levels are generally low.

Nursing Mothers:   It is not known whether erythromycin is excreted in human milk after topical application. However, erythromycin is excreted in human milk following oral and parenteral erythromycin administration. Therefore, caution should be exercised when erythromycin is administered to a nursing woman.

Pediatric Use:   Safety and effectiveness in children have not been established.

This monograph has been modified to include the generic and brand name in many instances.

OverDose

No Information Provided.

ContrainDications

EMGEL (erythromycin) Topical Gel is contraindicated in those individuals who have shown hypersensitivity to any of its components.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

The exact mechanism by which erythromycin reduces lesions of acne vulgaris is not fully known; however, the effect appears to be due in part to the antibacterial activity of the drug.

Microbiology:   Erythromycin appears to inhibit protein synthesis in susceptible organisms by reversibly binding to ribosomal subunits, thereby inhibiting translocation of aminoacyl transfer-RNA and inhibiting polypeptidesynthesis. Antagonism has been demonstrated between erythromycin, lincomycin, chloramphenicol, and clindamycin.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

Patients using ERYGEL® Topical Gel should receive the following information and instructions:

  1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes, nose, mouth, and allmucous membranes.
  2. This medication should not be used for any disorder other than that for which it was prescribed.
  3. Patients should not use any other topical acne medication unless otherwise directed by their physician.
  4. Patients should report to their physician any signs of local adverse reactions.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

 

ERYTHROMYCIN BASE GEL - TOPICAL

 

(eh-rith-row-MY-sin)

 

COMMON BRAND NAME(S): A/T/S, Emgel, Erygel

 

USES: This medication is used to treat acne. It helps to reduce the number of pimples. Erythromycin is an antibiotic (macrolide-type). It works by stopping the growth of bacteria. This product contains a large amount of alcohol which dries extra oils from the skin.

 

HOW TO USE: This medication is for use on the skin only. Clean and dry the affected area as directed. Then apply a thin layer of the medication on the skin, usually once or twice a day or as directed by your doctor. Wash your hands after use.

Do not use large amounts or apply this more often or for a longer period than directed. Your condition will not clear faster, but the risk of side effects may be increased.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day.

Avoid getting this medication in your eyes or inside the nose or mouth. If this occurs, rinse thoroughly with water.

Inform your doctor if your condition does not improve or if it worsens. It may take up to 3 months of regular use before the full benefits of this medication take effect.

Consumer Overview Side Effect

SIDE EFFECTS: This medication may cause burning, redness, itching, or dry/peeling/oily skin, especially in the first few days as your body adjusts to the medication. Eye irritation may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Rarely, use of this medication may result in other types of skin infections (fungal or other bacterial infections). Contact your doctor if you noti

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

No Information Available!

Patient Detailed How Take

No Information Available!

Patient Detailed Avoid Taking

No Information Available!

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