Drugs Details

Drugs Info of Baci-IM
Drugs Details
  • Drugs Type  : FDA
  • Date : 24th Dec 2014 11:21 pm
  • Brand Name : Baci-IM
  • Generic Name : bacitracin (injection) (Pronunciation: BAS i TRAY sin)
Descriptions

Sterile Bacitracin USP is an antibiotic for intramuscular administration. Bacitracin is derived from cultures of Bacillus subtilis (Tracey). It is a white to pale buff, hygroscopic powder, odorless or having a slight odor. It is freely soluble in water; insoluble in acetone, chloroform, and ether. While soluble in alcohol, methanol, and glacial acetic acid, there is some insoluble residue. It is precipitated from its solutions and inactivated by many of the heavy metals.

The structural formula is:

Bacitracin structural formula illustration

bacitracin A

The molecular formula is: C66H103N17O16S. Bacitracin is comprised of a polypeptide complex and Bacitracin A is the major component in this complex. The molecular weight of Bacitracin A is 1422.71.

What are the possible side effects of bacitracin injection (Baci-IM)?

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.

While receiving bacitracin injection, your child will be watched for the following serious side effects:

  • urinating more than usual or more often;
  • urinating less than usual, or not at all (fewer wet diapers);
  • blood in the urine;
  • lower back pain; or
  • painful urination.

Less serious side effects include:

  • nausea, vomiting;
  • mild skin rash;...

Read All Potential Side Effects and See Pictures of Bacitracin »

This monograph has been modified to include the generic and brand name in many instances.

Indications

In accord with the statements in the "Warning Box" the use of intramuscular bacitracin is limited to the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bacitracin and other antibacterial drugs, Bacitracin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy

Dosage Administration

TO BE ADMINISTERED INTRAMUSCULARLY ONLY

Infant dose: For infants under 2500 grams-900 units/kg/24 hours in 2 or 3 divided doses. For infants over 2500 grams-1,000 units/kg/24 hours, in 2 or 3 divided doses. Intramuscular injections of the solution should be given in the upper outer quadrant of the buttocks, alternating right and left and avoiding multiple injections in the same region because of the transient pain following injection.

Preparation of Solutions-Should be dissolved in sodium chloride injection containing 2 percent procaine hydrochloride. The concentration of the antibiotic in the solution should not be less than 5,000 units per mL nor more than 10,000 units per mL.

Diluents containing parabens should not be used to reconstitute bacitracin; cloudy solutions and precipitate formation have occurred.

Reconstitution of the 50,000 unit vial with 9.8 mL of diluent will result in a concentration of 5,000 units per mL.

Solutions are stable for one week when stored in a refrigerator 2° to 8°C (36° to 46°F).

How Supplied

Sterile Bacitracin USP is available in a vial containing 50,000 units (NDC 0009-0233-01). Store the unreconstituted product in a refrigerator 2° to 8°C (36° to 46°F).

Pharmacia & Upjohn Company, A subsidiary of Pharmacia Corporation, Kalamazoo, Michigan 49001, USA. Revised September 2003. FDA Rev date: 4/5/2000

This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Nephrotoxic reactions. Albuminuria, cylindruria, azotemia. Rising blood levels without any increase in dosage.

Other reactions. Nausea and vomiting. Pain at site of injection. Skin rashes.

Read the Bacitracin (bacitracin) Side Effects Center for a complete guide to possible side effects

Interactions

No information provided.

This monograph has been modified to include the generic and brand name in many instances.

Warnings

No information provided.

Precautions

See "Warning Box" for precautions in regard to kidney toxicity associated with intramuscular use of bacitracin.

Adequate fluid intake should be maintained orally, or if necessary, by parenteral method.

As with other antibiotics, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be instituted.

Prescribing Bacitracin in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

This monograph has been modified to include the generic and brand name in many instances.

OverDose

No information provided.

ContrainDications

This drug is contraindicated in those individuals with a history of previous hypersensitivity or toxic reaction to it.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

Bacitracin exerts pronounced antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. However, among systemic diseases, only staphylococcal infections qualify for consideration of bacitracin therapy. Bacitracin is assayed against a standard and its activity is expressed in units, 1 mg having a potency of not less than 50 units.

Susceptibility plate testing: If the Kirby-Bauer method of disk susceptibility is used, a 10 unit bacitracin disk should give a zone of over 13 mm when tested against a bacitracin-susceptible strain of Staphylococcus aureus. Absorption of bacitracin following intramuscular injection is rapid and complete. A dose of 200 or 300 units/kg every 6 hours gives serum levels of 0.2 to 2 mcg/mL in individuals with normal renal function. The drug is excreted slowly by glomerular filtration. It is widely distributed in all body organs and is demonstrable in ascitic and pleural fluids after intramuscular injection.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

Patients should be counseled that antibacterial drugs including Bacitracin should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Bacitracin is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Bacitracin or other antibacterial drugs in the future.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

No Information Available!

Consumer Overview Side Effect

No Information Available!

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

Brand Names: Baci-IM

Generic Name: bacitracin (injection) (Pronunciation: BAS i TRAY sin)

  • What is bacitracin (Bacitracin)?
  • What are the possible side effects of bacitracin injection (Bacitracin)?
  • What is the most important information I should know about bacitracin injection (Bacitracin)?
  • What should I discuss with my health care provider before receiving bacitracin injection (Bacitracin)?
  • How is bacitracin injection given (Bacitracin)?
  • What happens if I miss a dose (Bacitracin)?
  • What happens if I overdose (Bacitracin)?
  • What should I avoid while receiving bacitracin injection (Bacitracin)?
  • What other drugs will affect bacitracin injection (Bacitracin)?
  • Where can I get more information?

What is bacitracin (Bacitracin)?

Bacitracin injection is an antibiotic that treats staph infection caused by a bacteria called staphylococcus (STAF-il-oh-KOK-us).

Bacitracin injection is used in infants to treat pneumonia. It is also used to treat an infection that causes pus to build up between the lungs and the membrane that covers them.

Bacitracin injection may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of bacitracin injection (Bacitracin)?

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.

While receiving bacitracin injection, your child will be watched for the following serious side effects:

  • urinating more than usual or more often;
  • urinating less than usual, or not at all (fewer wet diapers);
  • blood in the urine;
  • lower back pain; or
  • painful urination.

Less serious side effects include:

  • nausea, vomiting;
  • mild skin rash; or
  • pain, burning, or swelling where the medicine was injected.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Bacitracin (bacitracin) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about bacitracin injection (Bacitracin)?

Before your child receives bacitracin injection, tell the doctor if the child has a history of kidney disease.

Many other drugs can damage the kidneys and should not be used together with bacitracin. Tell your doctor if your child is receiving chemotherapy, medicines used to treat a bowel disorder, medications to prevent organ transplant rejection, antiviral medications, or any other injected antibiotics.

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue, or throat.

Serious side effects of bacitracin injection include urinating less than usual or not at all, blood in the urine, lower back pain, or painful urination.

Make sure your child receives this medication for the entire length of time prescribed by the doctor. Your child's symptoms may get better before the infection is completely treated. Bacitracin injection will not treat a viral infection such as the common cold or flu.

Side Effects Centers
  • Bacitracin

Patient Detailed How Take

What should I discuss with my health care provider before receiving bacitracin injection (Bacitracin)?

Your child should not receive this medication if he or she is allergic to bacitracin.

Before receiving bacitracin injection, tell your child's doctor if the child is allergic to any drugs, or if your child has a history of kidney disease. If your child has either of these conditions, he or she may not be able to receive bacitracin, or may need dosage adjustments or special tests during treatment.

How is bacitracin injection given (Bacitracin)?

This medication is given as an injection into a muscle. A doctor, nurse, or other healthcare provider will give your child this injection.

Lung infections in infants are serious conditions, and your child will most likely be kept in the hospital while being treated with bacitracin injection.

To be sure this medication is not causing harmful effects, your child's kidney function may need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Make sure your child receives this medication for the entire length of time prescribed by the doctor. Your child's symptoms may get better before the infection is completely treated. Bacitracin injection will not treat a viral infection such as the common cold or flu.

Side Effects Centers
  • Bacitracin

Patient Detailed Avoid Taking

What happens if I miss a dose (Bacitracin)?

Since bacitracin injection is usually given in a hospital, it is not likely your child will miss a dose.

What happens if I overdose (Bacitracin)?

Tell your child's caregivers right away if you think the child has received too much of this medicine.

What should I avoid while receiving bacitracin injection (Bacitracin)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while your child is receiving bacitracin injection.

What other drugs will affect bacitracin injection (Bacitracin)?

Before your child receives bacitracin, tell the doctor if your child is receiving any of the following drugs:

  • cancer medications (chemotherapy);
  • medicines used to treat a bowel disorder, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);
  • medicines used to prevent organ transplant rejection, such as sirolimus (Rapamune) or tacrolimus (Prograf);
  • any other injected antibiotics such as amikacin (Amikin), amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet), or streptomycin; or
  • antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir).

Many of these other drugs can damage the kidneys. If your child is receiving any of these drugs, he or she may not be able to receive bacitracin, or may need dosage adjustments or special tests during treatment.

There may be other drugs that can affect bacitracin injection. Tell your doctor about all your child's prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your child's doctor.

Where can I get more information?

Your pharmacist can provide more information about bacitracin injection.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 1.04. Revision date: 12/15/2010.

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