Drugs Details

Drugs Info of Magnesium Sulfate-Sodium Chloride, Sulfamag
Drugs Details
  • Drugs Type  : Multum
  • Date : 21st Feb 2015 12:30 am
  • Brand Name : Magnesium Sulfate-Sodium Chloride, Sulfamag
  • Generic Name : magnesium sulfate (injection) (Pronunciation: mag NEE see um SUL fate)
Descriptions

Magnesium Sulfate Injection, USP (50%) for IV and IM use is a sterile concentrated solution of magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) USP. Each mL contains: magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) (heptahydrate) 500 mg, which provides 4.06 mEq each of magnesium (Mg++) and sulfate (SO4=), water for injection q.s. The pH (5.5 - 7.0) is adjusted with sulfuric acid and/or sodium hydroxide. The solution contains no bacteriostatic agent or other preservatives. The molecular formula is MgSO4•7H2O and the molecular weight is 246.47.

 

What are the possible side effects of magnesium sulfate injection (Magnesium Sulfate-Sodium Chloride, Sulfamag)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have a serious side effect such as:

  • feeling like you might pass out;
  • sweating, anxiety, cold feeling;
  • flushing (warmth, redness, or tingly feeling);
  • weak or shallow breathing;
  • extreme drowsiness, feeling very weak; or
  • numbness or tingly feeling around your mouth, muscle tightness or...

Read All Potential Side Effects and See Pictures of Magnesium Sulfate »

 

This monograph has been modified to include the generic and brand name in many instances.

Indications

Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated in the following conditions:

Convulsions (treatment) - Intravenous magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children.

Hypomagnesemia (prophylaxis and treatment) - Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those ofhypocalcemia.

Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is also used to prevent or treat magnesium deficiency in patients receiving total parenteral nutrition.

Tetany, uterine (treatment) - Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated in uterine tetany as a myometrial relaxant.

Dosage Administration

Intramuscular: Adults and older children: For severe hypomagnesemia, 1 to 5 g (2 to 10 mLof 50% solution) daily in divided doses; administration is repeated daily until serum levels have returned to normal. If deficiency is not severe, 1 g (2 mL of 50% solution) can be given once or twice daily. Serum magnesium levels should serve as a guide to continued dosage.

Intravenous: 1 to 4 g magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) may be given intravenously in 10% to 20% solution, but only with great caution; the rate should not exceed 1.5 mL of 10% solution or equivalent per minute until relaxation is obtained.

Intravenous Infusion: 4 g in 250 mL of 5% Dextrose Injection at a rate not exceeding 3 mL per minute.

Usual Dose Range: 1 to 40 g daily.

Electrolyte Replenisher: Intramuscular 1 to 2 g in 50% solution four times a day until serum magnesium is within normal limits.

Usual Pediatric Dose: Intramuscular 20 to 40 mg per kg of body weight in a 20% solution repeated as necessary.

For Eclampsia: Initially 1 to 2 g in 25% or 50% solution is given intramuscularly. Subsequently, 1 g is given every 30 minutes until relief is obtained. The blood pressure should be monitored after each injection.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

 
 

How Supplied

PRODUCT NO. VIAL SIZES  
NDC 0517-2602-25 2 mLSingle Dose Vial Boxes of 25
NDC 0517-2610-25 10 mLSingle Dose Vial Boxes of 25
NDC 0517-2650-25 50 mLSingle Dose Vial Boxes of 25

 

Store at controlled room temperature 15°-30°C (59°-86°F) (See USP). 
Discard unused portion.

Manufacturer: n/a. Rev 2/00. FDA Rev date: n/a

This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Flushing, sweating, sharply lowered blood pressure, hypothermia, stupor and ultimately, respiratory depression.

Read the Magnesium Sulfate (magnesium sulfate injection) Side Effects Center for a complete guide to possible side effects

Learn More »
 
 
 

Interactions

No information provided.

This monograph has been modified to include the generic and brand name in many instances.

Warnings

Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) should be given very cautiously in the presence of serious impairment of renal function since it is excreted almost entirely by the kidneys.

The principle hazard in parenteral magnesium therapy is the production of abnormally high levels of magnesium in the plasma. Such high levels may cause flushing, sweating, hypotension, circulatory collapse and depression ofcardiac and central nervous system function. The most immediate danger to life is respiratory depression.

During the period of parenteral therapy with magnesium salts, the patient should be watched carefully. A preparation of calcium, such as the gluconate or gluceptate should be at hand for intravenous administration as anantidote.

In the presence of severe renal insufficiency, no more than 20 grams of magnesium should be given within a forty-eight hour period. In eclampsia, however, renal function is not seriously impaired and magnesium may be more rapidly excreted.

This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphatesolutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

Precautions

When barbiturates, narcotics, or other hypnotics (or systemic anesthetics) are to be given in conjunction with magnesium, their dosage should be adjusted with caution because of the additive central depressive effects of magnesium.

Pregnancy - Teratogenic effects: Pregnancy category C. Animal reproduction studies have not been conducted with Magnesium Sulfate Injection, USP 50%. It is also not known whether Magnesium Sulfate Injection, USP 50% can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Magnesium Sulfate Injection, USP 50% should be given to a pregnant woman only if clearly needed.

This monograph has been modified to include the generic and brand name in many instances.

 
 

OverDose

No information provided.

ContrainDications

Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) should not be administered parenterally in patients with heart block or myocardial damage.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

Magnesium is the second most plentiful cation of the intracellular fluids. It isessential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Deficits are accompanied by a variety of structural and functional disturbances.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

No information provided. Please refer to the WARNINGS andPRECAUTIONS sections.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

No Information Available!

Consumer Overview Side Effect

No Information Available!

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

Brand Names: Magnesium Sulfate-Sodium Chloride, Sulfamag

Generic Name: magnesium sulfate (injection) (Pronunciation: mag NEE see um SUL fate)

  • What is magnesium sulfate injection (Magnesium Sulfate)?
  • What are the possible side effects of magnesium sulfate injection (Magnesium Sulfate)?
  • What is the most important information I should know about magnesium sulfate injection (Magnesium Sulfate)?
  • What should I discuss with my healthcare provider before receiving magnesium sulfate injection (Magnesium Sulfate)?
  • How is magnesium sulfate injection given (Magnesium Sulfate)?
  • What happens if I miss a dose (Magnesium Sulfate)?
  • What happens if I overdose (Magnesium Sulfate)?
  • What should I avoid while receiving magnesium sulfate injection (Magnesium Sulfate)?
  • What other drugs will affect magnesium sulfate injection (Magnesium Sulfate)?
  • Where can I get more information?

What is magnesium sulfate injection (Magnesium Sulfate)?

 

Magnesium is a naturally occurring mineral that is important for many systems in the body especially the muscles and nerves.

Magnesium sulfate injection is used to treat hypomagnesemia (low levels of magnesium in your blood).

Magnesium sulfate injection is also used to prevent seizures in pregnant women with conditions such as pre-eclampsia, eclampsia, or toxemia of pregnancy.

Magnesium sulfate injection may also be used for purposes not listed in this medication guide.

What are the possible side effects of magnesium sulfate injection (Magnesium Sulfate)?

 

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have a serious side effect such as:

  • feeling like you might pass out;
  • sweating, anxiety, cold feeling;
  • flushing (warmth, redness, or tingly feeling);
  • weak or shallow breathing;
  • extreme drowsiness, feeling very weak; or
  • numbness or tingly feeling around your mouth, muscle tightness or contraction, overactive reflexes.

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Magnesium Sulfate (magnesium sulfate injection) Side Effects Center for a complete guide to possible side effects

Learn More »
 

What is the most important information I should know about magnesium sulfate injection (Magnesium Sulfate)?

 

Magnesium sulfate is injected into a muscle or into a vein through an IV. You will receive this injection in a clinic or hospital setting.

If possible before you receive magnesium sulfate, tell your doctor if you have kidney disease, heart disease, a stomach or intestinal disorder, or if you are dehydrated.

Tell your doctor about all other medicines you use, especially an IV (injected) antibiotic.

Tell your doctor if you drink alcohol or caffeine drinks regularly, if you smoke, or if you use any street drugs. These factors can affect the way magnesium sulfate injection works in your body.

Side Effects Centers
  • Magnesium Sulfate

Patient Detailed How Take

What should I discuss with my healthcare provider before receiving magnesium sulfate injection (Magnesium Sulfate)?

 

If possible before you receive magnesium sulfate, tell your doctor if you have:

  • kidney disease;
  • heart disease;
  • a stomach or intestinal disorder; or
  • if you are dehydrated.

FDA pregnancy category A. Magnesium sulfate is not expected to harm an unborn baby.

Magnesium sulfate can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is magnesium sulfate injection given (Magnesium Sulfate)?

 

Magnesium sulfate is injected into a muscle or into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving magnesium sulfate.

Side Effects Centers
  • Magnesium Sulfate

Patient Detailed Avoid Taking

ISS A DOSE

In this Article

  • What is magnesium sulfate injection (Magnesium Sulfate)?
  • What are the possible side effects of magnesium sulfate injection (Magnesium Sulfate)?
  • What is the most important information I should know about magnesium sulfate injection (Magnesium Sulfate)?
  • What should I discuss with my healthcare provider before receiving magnesium sulfate injection (Magnesium Sulfate)?
  • How is magnesium sulfate injection given (Magnesium Sulfate)?
  • What happens if I miss a dose (Magnesium Sulfate)?
  • What happens if I overdose (Magnesium Sulfate)?
  • What should I avoid while receiving magnesium sulfate injection (Magnesium Sulfate)?
  • What other drugs will affect magnesium sulfate injection (Magnesium Sulfate)?
  • Where can I get more information?

What happens if I miss a dose (Magnesium Sulfate)?

 

Since magnesium sulfate is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose (Magnesium Sulfate)?

 

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving magnesium sulfate injection (Magnesium Sulfate)?

 

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect magnesium sulfate injection (Magnesium Sulfate)?

 

Tell your doctor if you drink alcohol or caffeine drinks regularly, if you smoke, or if you use any street drugs. These factors can affect the way magnesium sulfate injection works in your body.

Tell your doctor about all other medicines you use, especially an IV (injected) antibiotic, such as :

  • amikacin (Amikin);
  • gentamicin (Garamycin);
  • kanamycin (Kantrex);
  • neomycin (Neo Fradin, Neo Tab);
  • paromomycin (Humatin, Paromycin);
  • streptomycin; or
  • tobramycin (Nebcin, Tobi).

This list is not complete and other drugs may interact with magnesium sulfate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

 

Your doctor or pharmacist can provide more information about magnesium sulfate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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