Drugs Details

Drugs Info of Neosporin Ophthalmic, Ocu-Spore-G
Drugs Details
  • Drugs Type  : Multum
  • Date : 24th Feb 2015 04:45 am
  • Brand Name : Neosporin Ophthalmic, Ocu-Spore-G
  • Generic Name : gramicidin, neomycin, and polymyxin B ophthalmic (Pronunciation: gram i SYE din, NEE oh MYE sin, POL ee MIX in B off THAL mik)
Descriptions

NEOSPORIN Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) (neomycin and polymyxin B sulfates and bacitracin zinc ophthalmic ointment) is a sterile antimicrobial ointment for ophthalmic use. Each gram contains: neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, bacitracin zinc equivalent to 400 bacitracin units, and white petrolatum, q.s.

Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of Streptomyces fradiae Waksman (Fam. Streptomycetaceae). It has a potency equivalent of not less than 600 µg of neomycin standard per mg, calculated on an anhydrous basis. The structural formulae are:

 

Neomycin sulfate Structural Formula Illustration

Polymyxin B sulfate is the sulfate salt of polymyxin B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formulae are:

 

Polymyxin B sulfate Structural Formula Illustration

Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the licheniformis group of Bacillus subtilis var Tracy. It has a potency of not less than 40 bacitracin units per mg. The structural formula is:

 

Bacitracin zinc Structural Formula Illustration

What are the possible side effects of gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic, Ocu-Spore-G)?

Serious side effects are not expected with this medication.

Commonly, some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling or crusting, tearing, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Neosporin Ophthalmic Ointment »

What are the precautions when taking neomycin, polymyxin and bacitracin zinc ophthalmic ointment (Neosporin Ophthalmic Ointment)?

Before using this medication, tell your doctor or pharmacist if you are allergic to neomycin, bacitracin, or polymyxin; or to aminoglycoside antibiotics (e.g., gentamicin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and...

Read All Potential Precautions of Neosporin Ophthalmic Ointment »

This monograph has been modified to include the generic and brand name in many instances.

Indications

NEOSPORIN Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.

Dosage Administration

Apply the ointment every 3 or 4 hours for 7 to 10 days, depending on the severity of the infection.

How Supplied

Tube of 1/8 oz (3.5 g) with ophthalmic tip (NDC 61570-046-35).

Store at 15° to 25°C (59° to 77°F).

Prescribing information as of August 2003. Distributed by Monarch Pharmaceuticals, Inc., Bristol, TN 37620 (A wholly owned subsidiary of King Pharmaceuticals, Inc.). FDA revision date: 4/30/2004

This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Adverse reactions have occurred with the anti-infective components of NEOSPORIN Ophthalmic Ointment. The exact incidence is not known. Reactions occurring most often are allergic sensitization reactions including itching, swelling, and conjunctival erythema (see WARNINGS). More serious hypersensitivity reactions, including anaphylaxis, have been reported rarely.

Local irritation on instillation has also been reported.

Read the Neosporin Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) Side Effects Center for a complete guide to possible side effects

Learn More »

Interactions

No information provided.

This monograph has been modified to include the generic and brand name in many instances.

Warnings

NOT FOR INJECTION INTO THE EYE. NEOSPORIN Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) should never be directly introduced into the anterior chamber of the eye. Ophthalmic ointments may retard corneal wound healing.

Topical antibiotics, particularly neomycin sulfate, may cause cutaneous sensitization. A precise incidence of hypersensitivity reactions (primarily skin rash) due to topical antibiotics is not known. The manifestations of sensitization to topical antibiotics are usually itching, reddening, and edema of the conjunctiva and eyelid. A sensitization reaction may manifest simply as a failure to heal. During long-term use of topical antibiotic products, periodic examination for such signs is advisable, and the patient should be told to discontinue the product if they are observed. Symptoms usually subside quickly on withdrawing the medication. Application of products containing these ingredients should be avoided for the patient thereafter (see PRECAUTIONS: General).

Precautions

General: As with other antibiotic preparations, prolonged use of NEOSPORIN Ophthalmic Ointment may result in overgrowth of nonsusceptible organisms including fungi. If superinfection occurs, appropriate measures should be initiated.

Bacterial resistance to NEOSPORIN Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) may also develop. If purulent discharge, inflammation, or pain becomes aggravated, the patient should discontinue use of the medication and consult a physician.

There have been reports of bacterial keratitis associated with the use of topical ophthalmic products in multiple-dose containers which have been inadvertently contaminated by patients, most of whom had a concurrent corneal disease or a disruption of the ocular epithelial surface (see PRECAUTIONS: INFORMATION FOR PATIENTS).

Allergic cross-reactions may occur which could prevent the use of any or all of the following antibiotics for the treatment of future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin.

Carcinogenesis, Mutagenesis, Impairment of Fertility: Long-term studies in animals to evaluate carcinogenic or mutagenic potential have not been conducted with polymyxin B sulfate or bacitracin. Treatment of cultured human lymphocytes in vitro with neomycin increased the frequency of chromosome aberrations at the highest concentration (80 µg/mL) tested; however, the effects of neomycin on carcinogenesis and mutagenesis in humans are unknown.

Polymyxin B has been reported to impair the motility of equine sperm, but its effects on male or female fertility are unknown. No adverse effects on male or female fertility, litter size or survival were observed in rabbits given bacitracin zinc 100 gm/ton of diet.

Pregnancy: Teratogenic Effects: Pregnancy Category C. Animal reproduction studies have not been conducted with neomycin sulfate, polymyxin B sulfate, or bacitracin. It is also not known whether NEOSPORIN Ophthalmic Ointment can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. NEOSPORIN Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) should be given to a pregnant woman only if clearly needed.

Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when NEOSPORIN Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) is administered to a nursing woman.

Pediatric Use: Safety and effectiveness in pediatric patients have not been established.

Geriatric Use: No overall differences in safety or effectiveness have been observed between elderly and younger patients.

This monograph has been modified to include the generic and brand name in many instances.

OverDose

No information provided.

ContrainDications

NEOSPORIN Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) is contraindicated in individuals who have shown hypersensitivity to any of its components.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

A wide range of antibacterial action is provided by the overlapping spectra of neomycin, polymyxin B sulfate, and bacitracin.

Neomycin is bactericidal for many gram-positive and gram-negative organisms. It is an aminoglycoside antibiotic which inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code.

Polymyxin B is bactericidal for a variety of gram-negative organisms. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane.

Bacitracin is bactericidal for a variety of gram-positive and gram-negative organisms. It interferes with bacterial cell wall synthesis by inhibition of the regeneration of phospholipid receptors involved in peptidoglycan synthesis.

Microbiology: Neomycin sulfate, polymyxin B sulfate, and bacitracin zinc together are considered active against the following microorganisms: Staphylococcus aureus, streptococci including Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. The product does not provide adequate coverage against Serratia marcescens.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

Patients should be instructed to avoid allowing the tip of the dispensing container to contact the eye, eyelid, fingers, or any other surface. The use of this product by more than one person may spread infection.

Patients should also be instructed that ocular products, if handled improperly, can become contaminated by common bacteria known to cause ocular infections. Serious damage to the eye and subsequent loss of vision may result from using contaminated products (see PRECAUTIONS: General).

If the condition persists or gets worse, or if a rash or allergic reaction develops, the patient should be advised to stop use and consult a physician. Do not use this product if you are allergic to any of the listed ingredients.

Keep tightly closed when not in use. Keep out of reach of children.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

 

NEOMYCIN/BACITRACIN/POLYMYXIN - OPHTHALMIC OINTMENT

 

(nee-oh-MY-sin/bass-eh-TRAY-sin/paw-lee-MIX-in)

 

USES: This medication is used to treat eye infections. This product contains neomycin, bacitracin, and polymyxin, antibiotics that work by stopping the growth of bacteria.

This medication treats only bacterial eye infections. It will not work for other types of eye infections (e.g., infections caused by viruses, fungi, mycobacteria). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

 

HOW TO USE: This medication is applied to the eye(s) as directed by your doctor. Dosage is based on your medical condition and response to therapy.

Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to manufacturer's directions, and check with your doctor before you begin using them again.

To apply the eye ointment, wash your hands first. To avoid contamination, be careful not to touch the tube tip or let it touch your eye or any other surface. Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Place a 1/2 inch (1.5 centimeters) strip of ointment into the pouch by squeezing the tube gently. Close the eye and roll the eyeball in all directions to spread the medication. Try not to blink and do not rub the eye. Repeat these steps for your other eye if so directed. Wipe the tip of the ointment tube with a clean tissue to remove extra medication before recapping it. Apply as often as directed by your doctor.

If you are using another kind of eye medication (e.g., drops or ointments), apply the eye drops first and wait at least 5 minutes before applying this eye ointment. Use eye drops before eye ointments to allow the eye drops to enter the eye. If you are using another type of eye ointment, wait at least 10 minutes after using this medication before applying it.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too soon may allow bacteria to continue to grow, which may result in a return of the infection.

Inform your doctor immediately if your condition does not improve in a few days or if you develop new or worsening eye symptoms (e.g., discharge, swelling, redness, pain).

Consumer Overview Side Effect

SIDE EFFECTS: Stinging/burning of the eyes for 1 to 2 minutes or temporary blurred vision may occur when this medication is applied. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat/eye/eyelid), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

 

Read the Neosporin Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) Side Effects Center for a complete guide to possible side effects

Learn More »

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to neomycin, bacitracin, or polymyxin; or to aminoglycoside antibiotics (e.g., gentamicin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.

Consumer Overview Missed Dose

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

 

OVERDOSE: This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

 

NOTES: Do not share this medication with others.

This medication has been prescribed for your current condition only. Throw away any unused medication after treatment is completed. Do not use it later for another infection. A different medication may be necessary in that case.

 

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

 

STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from heat and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.

Patient Detailed Side Effect

Brand Names: Neosporin Ophthalmic, Ocu-Spore-G

Generic Name: gramicidin, neomycin, and polymyxin B ophthalmic (Pronunciation: gram i SYE din, NEE oh MYE sin, POL ee MIX in B off THAL mik)

  • What is gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?
  • What are the possible side effects of gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?
  • What is the most important information I should know about gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?
  • Who should not use gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?
  • How should I use gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?
  • What happens if I miss a dose (Neosporin Ophthalmic Ointment)?
  • What happens if I overdose (Neosporin Ophthalmic Ointment)?
  • What should I avoid while using gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?
  • What other drugs will affect gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?
  • Where can I get more information?

What is gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?

Gramicidin, neomycin, and polymyxin B are all antibiotics. They are used to treat bacterial infections.

The ophthalmic form of gramicidin, neomycin, and polymyxin B is used to treat bacterial infections of the eyes.

Gramicidin, neomycin, and polymyxin B ophthalmic may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?

Serious side effects are not expected with this medication.

Commonly, some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling or crusting, tearing, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Neosporin Ophthalmic Ointment (neomycin, polymyxin and bacitracin zinc ophthalmic ointment) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?

Contact your doctor if your symptoms begin to get worse or if you do not see any improvement in your condition after a few days.

Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

Apply light pressure to the inside corner of your eye (near your nose) after each drop to prevent the liquid from draining down your tear duct.

Side Effects Centers
  • Neosporin Ophthalmic Ointment

Patient Detailed How Take

Who should not use gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?

Do not use gramicidin, neomycin, and polymyxin B ophthalmic if you have a viral or fungal infection in your eye. It is used to treat infections caused by bacteria only.

It is not known whether gramicidin, neomycin, and polymyxin B ophthalmic will harm an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant.

It is not known whether gramicidin, neomycin, and polymyxin B ophthalmic passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?

Use gramicidin, neomycin, and polymyxin B eyedrops exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using your eyedrops.

To apply the eyedrops:

  • Tilt your head back slightly and pull down on your lower eyelid. Position the dropper above your eye. Look up and away from the dropper. Squeeze out a drop and close your eye. Apply gentle pressure to the inside corner of your eye (near your nose) for about 1 minute to prevent the liquid from draining down your tear duct. If you are using more than one drop in the same eye or drops in both eyes, repeat the process with about 5 minutes between drops.

Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

Do not use any eyedrop that is discolored or has particles in it.

Store gramicidin, neomycin, and polymyxin B ophthalmic at room temperature away from moisture and heat. Keep the bottle properly capped.

Side Effects Centers
  • Neosporin Ophthalmic Ointment

Patient Detailed Avoid Taking

What happens if I miss a dose (Neosporin Ophthalmic Ointment)?

Apply the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not use a double dose of this medication.

What happens if I overdose (Neosporin Ophthalmic Ointment)?

An overdose of this medication is unlikely to occur. If you do suspect an overdose, wash the eye with water and call an emergency room or poison control center near you. If the drops have been ingested, drink plenty of fluid and call an emergency center for advice.

What should I avoid while using gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?

Do not touch the dropper to any surface, including your eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in your eye.

Use caution when driving, operating machinery, or performing other hazardous activities. Gramicidin, neomycin, and polymyxin B ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities.

Use caution with contact lenses. Wear them only if your doctor approves. After applying this medication, wait at least 15 minutes before inserting contact lenses.

Avoid other eye medications unless your doctor approves.

What other drugs will affect gramicidin, neomycin, and polymyxin B ophthalmic (Neosporin Ophthalmic Ointment)?

Avoid other eye medications unless they are approved by your doctor.

Drugs other than those listed here may also interact with gramicidin, neomycin, and polymyxin B ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about gramicidin, neomycin, and polymyxin B written for health professionals that you may read.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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