Drugs Details

Drugs Info of Papacon, Para-Time S. R., Pavabid Plateau, Pavacot, Pavagen
Drugs Details
  • Drugs Type  : Multum
  • Date : 6th Mar 2015 03:32 am
  • Brand Name : Papacon, Para-Time S. R., Pavabid Plateau, Pavacot, Pavagen
  • Generic Name : papaverine (Pronunciation: pa PAV uh reen)
Descriptions

Papaverine hydrochloride, C20H21NO4•HCl, is a white, crystalline powder, odorless, with a slight bitter taste and is soluble in water.

Each capsule contains: papaverine hydrochloride USP 150 mg.

Chemically, it is Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride. It has a molecular weight of 375.85. It has the following structural formula:

 

Papaverine Hydrochloride Structural Formula Illustration

Manufactured in a special base which is designed for prolonged release. Each capsule also contains the following inactive ingredients: FD&C blue No. 1, FD&C red No. 40, gelatin, pharmaceutical glaze, povidone, silicon dioxide, sodium lauryl sulfate, corn starch, sucrose and talc.

What are the possible side effects of papaverine (Papacon, Para-Time S. R., Pavabid Plateau, Pavacot, Pavagen)?

Stop taking papaverine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Stop taking papaverine and contact your doctor if your skin or eyes develop a yellow tint.

Other, less serious side effects may be more likely to occur. Continue to take papaverine and talk to your doctor if you experience

  • nausea, decreased appetite, diarrhea, or constipation;
  • dizziness or...

Read All Potential Side Effects and See Pictures of Papaverine »


This monograph has been modified to include the generic and brand name in many instances.

Indications

For the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias.

Dosage Administration

One capsule every 12 hours. In difficult cases administration may be increased to one capsule every 8 hours or two capsules every 12 hours.

How Supplied

Papaverine Hydrochloride Sustained Release Capsules are supplied as: 150 mg brown and clear capsules, imprinted E 5156 and are available in bottles of 100, 500 and 1000.

Storage

Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].

Protect from moisture.

To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc. at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Manufactured for: Sandoz Inc. Princeton, NJ 08540. Manufactured by: Epic Pharma, LLC. Laurelton, NY 11413. Rev. 11/08.


This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Although occurring rarely, the reported side effects of papaverine include nausea, abdominal distress, anorexia, constipation, malaise, drowsiness, vertigo, sweating, headache, diarrhea, skin rash, flushing of face, increase in heart rate and depth of respiration and slight increase in blood pressure.

Read the Papaverine (papaverine) Side Effects Center for a complete guide to possible side effects

Interactions

No information provided.


This monograph has been modified to include the generic and brand name in many instances.

Warnings

No information provided.

 

Precautions

Use with caution in patients with glaucoma. Hepatic hypersensitivity has been reported with gastrointestinal symptoms, jaundice, eosinophilia and altered liver function tests. Discontinue drug if these occur.


This monograph has been modified to include the generic and brand name in many instances.

OverDose

No information provided.

ContrainDications

Large doses can depress atrioventricular and intraventricular conduction and thereby produce serious arrhythmias.


This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

The main actions of papaverine are exerted on cardiac and smooth muscle. Like quinidine, papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one and unrelated to muscle innervation. Papaverine is practically devoid of effects on the central nervous system.

Papaverine relaxes the smooth musculature of the large blood vessels, especially coronary, systemic peripheral and pulmonary arteries. Perhaps by its direct vasodilating action on cerebral blood vessels, papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy.

The direct actions of papaverine on the heart to depress conduction and irritability and to prolong the refractory period of the myocardium provide the basis for its clinical trial in abrogating atrial and ventricular premature systoles and ominous ventricular arrhythmias. The coronary vasodilator action could be an additional factor of therapeutic value when such rhythms are secondary to insufficiency or occlusion of the coronary arteries.

In patients with acute coronary thrombosis, the occurrence of ventricular cardiac arrhythmias is serious and requires measures designed to decrease myocardial irritability. Papaverine may have advantages over quinidine used for a similar purpose, in that it may be given in an emergency by the intravenous route, does not depress myocardial contraction or cause cinchonism and produces coronary vasodilation.
This monograph has been modified to include the generic and brand name in many instances.

Patient Information

No information provided. Please refer to the PRECAUTIONS sections.
This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

No Information Available!

Consumer Overview Side Effect

No Information Available!

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

Brand Names: Papacon, Para-Time S. R., Pavabid Plateau, Pavacot, Pavagen

Generic Name: papaverine (Pronunciation: pa PAV uh reen)

  • What is papaverine (Papaverine)?
  • What are the possible side effects of papaverine (Papaverine)?
  • What is the most important information I should know about papaverine (Papaverine)?
  • Who should not take papaverine (Papaverine)?
  • How should I take papaverine (Papaverine)?
  • What happens if I miss a dose (Papaverine)?
  • What happens if I overdose (Papaverine)?
  • What should I avoid while taking papaverine (Papaverine)?
  • What other drugs will affect papaverine (Papaverine)?
  • Where can I get more information?

What is papaverine (Papaverine)?

Papaverine is in a class of drugs called vasodilators. Papaverine relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. These actions may help to increase the amount of oxygen-rich blood in your brain, heart, and muscles.

Papaverine may also be useful in treating conditions involving spasms of the intestines and urinary tract.

Papaverine may also be used for purposes other than those listed in this medication guide.

Papaverine 150 mg-URL

brown/clear, imprinted with TCL, 019

What are the possible side effects of papaverine (Papaverine)?

Stop taking papaverine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Stop taking papaverine and contact your doctor if your skin or eyes develop a yellow tint.

Other, less serious side effects may be more likely to occur. Continue to take papaverine and talk to your doctor if you experience

  • nausea, decreased appetite, diarrhea, or constipation;
  • dizziness or drowsiness;
  • headache;
  • sweating and flushing;
  • a rash; or
  • irregular heartbeats.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the Papaverine (papaverine) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about papaverine (Papaverine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Papaverine may cause dizziness. If you experience dizziness, avoid these activities.

If you experience dizziness, rise slowly from a sitting or lying position to avoid falling.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking papaverine.

Notify your doctor if you experience especially bothersome sweating, rash, flushing, headache, tiredness, yellowing of your skin, nausea, decreased appetite, diarrhea, or constipation.

Side Effects Centers
  • Papaverine

Patient Detailed How Take

Who should not take papaverine (Papaverine)?

Before taking this medication, tell your doctor if you have

  • heart disease or irregular heartbeats,
  • liver disease,
  • glaucoma, or
  • Parkinson's disease.

You may not be able to take papaverine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Papaverine is in the FDA pregnancy category C. This means that it is not known whether papaverine will harm an unborn baby. Do not take papaverine without first talking to your doctor if you are pregnant.

It is not known whether papaverine passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take papaverine (Papaverine)?

Take papaverine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

The regular-release form of papaverine is usually taken three to five times a day. The timed-release tablets and capsules are usually taken two or three times a day (every 8 to 12 hours). Follow your doctor's instructions.

Do not crush, chew, break, or open the timed-release tablets or capsules. Swallow them whole. They are specially formulated to release slowly in your body.

Store papaverine at room temperature away from moisture and heat.

Side Effects Centers
  • Papaverine

Patient Detailed Avoid Taking

What happens if I miss a dose (Papaverine)?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose (Papaverine)?

Seek emergency medical attention.

Symptoms of a papaverine overdose include drowsiness, weakness, double vision, poor coordination, headache, blue-colored lips or skin, and coma.

What should I avoid while taking papaverine (Papaverine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Papaverine may cause dizziness. If you experience dizziness, avoid these activities.

If you experience dizziness, rise slowly from a sitting or lying position to avoid falling.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking papaverine.

Do not crush, chew, break, or open the timed-release tablets or capsules. Swallow them whole. These are specially formulated to release slowly in your body.

What other drugs will affect papaverine (Papaverine)?

Papaverine may decrease the effects of levodopa (Dopar, Larodopa) which is used to treat Parkinson's disease. You may need a change in your levodopa dosage if you are taking levodopa.

Drugs other than those listed here may also interact with papaverine or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about papaverine written for health professionals that you may read.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 3.05. Revision date: 12/15/2010.

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Side Effects Centers
  • Papaverine

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