Drugs Details

Drugs Info of Paromycin
Drugs Details
  • Drugs Type  : FDA
  • Date : 6th Mar 2015 07:39 am
  • Brand Name : Paromycin
  • Generic Name : paromomycin (Pronunciation: PAR oh moe MYE sin)
Descriptions

Paromomycin sulfate (paromomycin sulfate (paromomycin sulfate capsules) capsules) is a broad spectrum antibiotic produced by Streptomyces riomosus var. paromomycinus. It is a white, amorphous, stable, water-soluble product. Paromomycin sulfate (paromomycin sulfate (paromomycin sulfate capsules) capsules) is designated chemically as O-2,6-Diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxystrepta-mine sulfate (salt). The molecular formula is C23H45N5O14 • xH2SO4, with a molecular weight of 615.64 (base). Its structural formula is:

 

Paromomycin Sulfate Structural Formula Illustration

Each capsule, for oral administration, contains paromomycin sulfate (paromomycin sulfate (paromomycin sulfate capsules) capsules) equivalent to 250 mg paromomycin. Each capsule also contains the following inactive ingredients: FD&C Green #3; FD&C Yellow #5 (tartrazine); gelatin, NF; and titanium dioxide, USP.

What are the possible side effects of paromomycin (Paromycin)?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • decreased hearing or ringing in the ears;
  • little or no urine production; or
  • dizziness.

Other less serious side effects may be more likely to occur. Continue to take paromomycin and talk to your doctor if you experience

  • nausea or vomiting;
  • diarrhea;...

Read All Potential Side Effects and See Pictures of Paromomycin Sulfate »


This monograph has been modified to include the generic and brand name in many instances.

Indications

Paromomycin sulfate (paromomycin sulfate (paromomycin sulfate capsules) capsules) is indicated for intestinal amebiasis—acute and chronic (NOTE—It is not effective in extraintestinal amebiasis); management of hepatic coma—as adjunctive therapy.

Dosage Administration

Intestinal amebiasis: Adults and Children: Usual dose—25 to 35 mg/kg body weight daily, administered in three doses with meals, for five to ten days.

Management of hepatic coma: Adults: Usual dose—4 g daily in divided doses, given at regular intervals for five to six days.

How Supplied

Paromomycin Sulfate (paromomycin sulfate (paromomycin sulfate capsules) capsules) Capsules, each contain paromomycin sulfate (paromomycin sulfate (paromomycin sulfate capsules) capsules) equivalent to 250 mg paromomycin. The capsule is green/yellow, imprinted “175” in black ink on the cap and body.

NDC 57664-175-08: Bottles of 100

Store at controlled room temperature 15°-30°C (59°-86°F).

Protect from moisture.

Caution—Federal law prohibits dispensing without prescription.

3/97. Caraco Pharmaceutical Laboratories, Ltd. Detroit, MI 48202. FDA revision date: n/a


This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Nausea, abdominal cramps, and diarrhea have been reported in patients on doses over 3 g daily.

Read the Paromomycin Sulfate (paromomycin sulfate capsules) Side Effects Center for a complete guide to possible side effects

Interactions

No information provided.


This monograph has been modified to include the generic and brand name in many instances.

Warnings

No information provided.

Precautions

The use of this antibiotic, as with other antibiotics, may result in an overgrowth of nonsusceptible organisms, including fungi. Constant observation of the patient is essential. If new infections caused by nonsusceptible organisms appear during therapy, appropriate measures should be taken.

The drug should be used with caution in individuals with ulcerative lesions of the bowel to avoid renal toxicity through inadvertent absorption.

This product contains FD&C Yellow No. 5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible persons. Although the overall incidence of FD&C Yellow No. 5 (tartrazine) sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity.


This monograph has been modified to include the generic and brand name in many instances.

OverDose

No information provided.

ContrainDications

Paromomycin sulfate (paromomycin sulfate (paromomycin sulfate capsules) capsules) is contraindicated in individuals with a history of previous hypersensitivity reactions to it. It is also contraindicated in intestinal obstruction.


This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin. It is poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
This monograph has been modified to include the generic and brand name in many instances.

Patient Information

No information provided. Please refer to the PRECAUTIONS section.
This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

No Information Available!

Consumer Overview Side Effect

No Information Available!

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

Brand Names: Paromycin

Generic Name: paromomycin (Pronunciation: PAR oh moe MYE sin)

  • What is paromomycin (Paromomycin Sulfate)?
  • What are the possible side effects of paromomycin (Paromomycin Sulfate)?
  • What is the most important information I should know about paromomycin (Paromomycin Sulfate)?
  • What should I discuss with my healthcare provider before taking paromomycin (Paromomycin Sulfate)?
  • How should I take paromomycin (Paromomycin Sulfate)?
  • What happens if I miss a dose (Paromomycin Sulfate)?
  • What happens if I overdose (Paromomycin Sulfate)?
  • What should I avoid while taking paromomycin (Paromomycin Sulfate)?
  • What other drugs will affect paromomycin (Paromomycin Sulfate)?
  • Where can I get more information?

What is paromomycin (Paromomycin Sulfate)?

Paromomycin is an antibiotic.

Paromomycin is used in the treatment of various intestinal infections. Paromomycin is also used in the treatment of certain liver problems.

Paromomycin may also be used for purposes other than those listed here.

Humatin 250 mg

brown/yellow, imprinted with PD 529

What are the possible side effects of paromomycin (Paromomycin Sulfate)?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • decreased hearing or ringing in the ears;
  • little or no urine production; or
  • dizziness.

Other less serious side effects may be more likely to occur. Continue to take paromomycin and talk to your doctor if you experience

  • nausea or vomiting;
  • diarrhea; or
  • itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Read the Paromomycin Sulfate (paromomycin sulfate capsules) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about paromomycin (Paromomycin Sulfate)?

Use caution when driving, operating machinery, or performing other hazardous activities. Paromomycin may cause dizziness. If you experience dizziness, avoid these activities and contact your doctor.

Side Effects Centers
  • Paromomycin Sulfate

Patient Detailed How Take

What should I discuss with my healthcare provider before taking paromomycin (Paromomycin Sulfate)?

Before taking paromomycin, tell your doctor if you have

  • stomach or intestinal problems such as stomach ulcer, inflammatory bowel disease, or intestinal blockage (obstruction);
  • kidney disease; or
  • liver disease.

You may not be able to take paromomycin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Do not take paromomycin without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Do not take paromomycin without first talking to your doctor if you are breast-feeding a baby.

How should I take paromomycin (Paromomycin Sulfate)?

Take paromomycin exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse, or pharmacist to explain them to you.

Take each dose with a full glass of water.

Take paromomycin with food.

It is important to take paromomycin regularly to get the most benefit.

Store paromomycin at room temperature away from moisture, heat, and direct light.

Side Effects Centers
  • Paromomycin Sulfate

Patient Detailed Avoid Taking

What happens if I miss a dose (Paromomycin Sulfate)?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose unless otherwise directed by your doctor.

What happens if I overdose (Paromomycin Sulfate)?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a paromomycin overdose are not known.

What should I avoid while taking paromomycin (Paromomycin Sulfate)?

Use caution when driving, operating machinery, or performing other hazardous activities. Paromomycin may cause dizziness. If you experience dizziness, avoid these activities and contact your doctor.

What other drugs will affect paromomycin (Paromomycin Sulfate)?

Talk to your doctor before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with paromomycin.

Where can I get more information?

Your pharmacist has additional information about paromomycin written for healthcare professionals that you may read.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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  • Paromomycin Sulfate

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