Drugs Details

Drugs Info of Calcium Gluconate
Drugs Details
  • Drugs Type  : FDA
  • Date : 5th Jan 2015 02:09 am
  • Brand Name : Calcium Gluconate
  • Generic Name : calcium gluconate (Pronunciation: KAL see um GLUE koe nate)
Descriptions

Calcium Gluconate is the calcium salt of gluconic acid, an oxidation product of glucose, and contains 9.3% calcium, which is about one-third of the calcium in strength of calcium chloride USP. Since it is soluble to the extent of only one part in 30 parts of cold water, the 10% solution is supersaturated and is stabilized by the addition of calcium saccharate tetrahydrate 0.46% w/v (which supplies calcium 6.2%). Each mL contains 98 mg of calcium gluconatemonohydrate, 4.6 mg of calcium saccharate tetrahydrate, and Water for Injection USP, q.s. Each mL provides 9.3 mg (0.465 milliequivalents) of calcium.

The 100 mL Pharmacy Bulk Package contains many single doses for use in a pharmacy admixture program in the preparation of parenteral fluids. See directions for dispensing from the 100 mL Pharmacy Bulk Package. pH is adjusted with sodium hydroxide and/or hydrochloric acid.

The structural formula is:

 

Calcium Gluconate Structural Formula Illustration
C12H22CaO14..........................430.38

What are the possible side effects of calcium gluconate ()?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

  • nausea or vomiting;
  • decreased appetite;
  • constipation;
  • dry mouth or increased thirst; or
  • increased urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Calcium Gluconate »

This monograph has been modified to include the generic and brand name in many instances.

Indications

Calcium gluconate is used to treat conditions arising from calcium deficiencies such as hypocalcemic tetany, hypocalcemia related to hypoparathyrodism and hypocalcemia due to rapid growth or pregnancy. It is also used in the treatment of black widow spider bites to relieve muscle cramping and as an adjunct in the treatment of rickets, osteomalacia, lead colic and magnesium sulfate overdosage. Calcium gluconate has also been employed to decrease capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses such as dermatitis herpetiformis and for pruritus of eruptions caused by certain drugs. In hyperkalemia, calcium gluconate may aid in antagonizing the cardiac toxicity provided the patient is not receiving digitalis therapy.

Dosage Administration

Calcium Gluconate should be administered intravenously either directly or by infusion. The dose is dependent upon the individual requirements of the patient. Calcium Gluconate may also be administered by intermittent infusion at a rate not exceeding 200 mg/min, or by continuous infusion.

DIRECTIONS FOR DISPENSING FROM 100 mL PHARMACY BULK PACKAGE - NOT FOR DIRECT INFUSION.

The 100 mL Pharmacy Bulk Package is for use in a Pharmacy Admixture Service only. The 100 mL Pharmacy Bulk Package should be suspended (inverted) by its IV hang label in a laminar flow hood or biological safety cabinet. Prior to entering a Pharmacy Bulk Package remove the flip-off seal and cleanse the rubber closure with a suitable antiseptic agent. Entry into the Pharmacy Bulk Package must be made with a sterile transfer set or other sterile dispensing device and the contents dispensed in aliquots using aseptic technique. Use of a syringe needle is not recommended as it may cause leakage. ANY UNUSED PORTION MUST BE DISCARDED WITHIN 4 HOURS AFTER INITIAL ENTRY. The date and the time initially opened should be recorded in the space provided on the Pharmacy Bulk Package label.

Usual Dosage

Adults: 500 mg - 2 grams (5-20 mL)

Children: 200-500 mg (2-5 mL)

Infants: not more than 200 mg (not more than 2 mL)

How Supplied

Calcium Gluconate Injection, USP 10%

NDC 0517-3910-25 10% 10 mL Single Dose Vials packed in boxes of 25
NDC 0517-3950-25 10% 50 mL Single Dose Vials packed in boxes of 25
NDC 0517-3900-25 10% 100 mL Pharmacy Bulk Package packed in boxes of 25

Supersaturated solutions are prone to precipitation.

NOTE: If crystallization has occurred, warming in a 60°C water bath for 15-30 minutes with occasional shaking, may dissolve the precipitate. Cool to body temperature before use. The injection must be clear at the time of use. Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.

No preservative added. Unused portion of vial should be discarded. Use only if solution is clear and seal intact.

Store at controlled room temperature 15º- 30ºC (59º- 86ºF) (See USP).

American Regent Laboratories, Inc. Shirley, NY 11967. Rev: 2/00

This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Patients may complain of tingling sensations, a sense of oppression or heat waves and a calcium or chalky taste following the intravenous administration of calcium gluconate.

Rapid intravenous injection of calcium salts may cause vasodilation, decreased blood pressure, bradycardia, cardiac arrhythmias, syncope and cardiac arrest. Use in digitalized patients may precipitate arrhythmias.

Local necrosis and abscess formation may occur with intramuscular injection.

Read the Calcium Gluconate (calcium gluconate) Side Effects Center for a complete guide to possible side effects

Learn More »

Interactions

The ionotropic and toxic effects of cardiac glycosides and calcium are synergistic and arrhythmias may occur if these drugs are given together (particularly when calcium is given intravenously). Intravenous administration of calcium should be avoided in patients receiving cardiac glycosides; if necessary, calcium should be given slowly in small amounts.

Calcium complexes tetracycline antibiotics rendering them inactive. The two drugs should not be given at the same time orally nor should they be mixed for parenteral administration.

Calcium Gluconate Injection has been reported to be incompatible with intravenous solutions containing various drugs. Published data are too varied and/or limited to permit generalizations, and specialized references should be consulted for specific information.

Drug/Laboratory Test Interactions

Transient elevations of plasma 11-hydroxy-corticosteroid levels (Glenn-Nelson technique) may occur when intravenous calcium is administered, but levels return to control values after one hour. In addition, intravenous calcium gluconate can produce false-negative values for serum and urinary magnesium.

This monograph has been modified to include the generic and brand name in many instances.

Warnings

For intravenous use only. Subcutaneous or intramuscular injection may cause severe necrosis and sloughing. This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

Precautions

General

To avoid undesirable reactions that may follow rapid intravenous administration of calcium gluconate, the drug should be given slowly, e.g., approximately 1.5 mL over a period of one minute. When injected intravenously, calcium gluconate should be injected through a small needle into a large vein in order to avoid too rapid increase in serum calcium and extravasation of calcium solution into the surrounding tissue with resultant necrosis.

Rapid injection of calcium gluconate may cause vasodilation decreased blood pressure, bradycardia, cardiac arrhythmias, syncope and cardiac arrest.

Because of the danger involved in simultaneous use of calcium salts and drugs of the digitalis group, a digitalized patient should not receive an intravenous injection of a calcium compound unless indications are clearly defined.

Pregnancy Category C

Animal reproduction studies have not been conducted with calcium gluconate. It is also not known whether calcium gluconate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Calcium gluconate should be given to a pregnant woman only if clearly needed.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when calcium gluconate is administered to a nursing woman.

This monograph has been modified to include the generic and brand name in many instances.

OverDose

No information provided.

ContrainDications

Calcium salts are contraindicated in patients with ventricular fibrillation or hypercalcemia. Intravenous administration of calcium is contraindicated when serum calcium levels are above normal.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

Calcium is the fifth most abundant element in the body and is essential for maintenance of the functional integrity of nervous, muscular and skeletal systems and cell membrane and capillary permeability. It is also an important activator in many enzymatic reactions and is essential to a number of physiologic processes including transmission of nerve impulses; contraction of cardiac, smooth and skeletal muscles; renal function; respiration and blood coagulation. Calcium also plays regulatory roles in the release and storage of neurotransmitters and hormones, in the uptake and binding of amino acids, and in cyanocobalamin (vitamin B12) absorption and gastrin secretion.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

No Information Available!

Consumer Overview Side Effect

No Information Available!

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

Brand Names:

Generic Name: calcium gluconate (Pronunciation: KAL see um GLUE koe nate)

  • What is calcium gluconate ?
  • What are the possible side effects of calcium gluconate ?
  • What is the most important information I should know about calcium gluconate ?
  • What should I discuss with my healthcare provider before taking calcium gluconate ?
  • How should I take calcium gluconate ?
  • What happens if I miss a dose ?
  • What happens if I overdose ?
  • What should I avoid while taking calcium gluconate ?
  • What other drugs will affect calcium gluconate ?
  • Where can I get more information?

What is calcium gluconate ?

Calcium is a mineral that is found naturally in foods. Calcium is necessary for many normal functions of your body, especially bone formation and maintenance. Calcium can also bind to other minerals (such as phosphate) and aid in their removal from the body.

Calcium gluconate is used to prevent and to treat calcium deficiencies.

Calcium gluconate may also be used for purposes not listed in this medication guide.

Calcium Gluconate 500 mg-ROX

oblong, white, imprinted with 54 372, 54372

What are the possible side effects of calcium gluconate ?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

  • nausea or vomiting;
  • decreased appetite;
  • constipation;
  • dry mouth or increased thirst; or
  • increased urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Calcium Gluconate (calcium gluconate) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about calcium gluconate ?

Do not take calcium gluconate or antacids that contain calcium without first asking your doctor if you also take other medicines. Calcium can make it harder for your body to absorb certain medicines.

Calcium gluconate works best if you take it with food.

Side Effects Centers
  • Calcium Gluconate

Patient Detailed How Take

What should I discuss with my healthcare provider before taking calcium gluconate ?

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

  • a history of kidney stones; or
  • a parathyroid gland disorder.

Talk to your doctor before taking calcium gluconate if you are pregnant. Your dose needs may be different during pregnancy.

Talk to your doctor before taking calcium gluconate if you are breast-feeding a baby. Your dose needs may be different while you are nursing.

How should I take calcium gluconate ?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Calcium gluconate works best if you take it with food.

Take calcium gluconate with a full glass of water.

Store at room temperature away from moisture and heat.

Side Effects Centers
  • Calcium Gluconate

Patient Detailed Avoid Taking

What happens if I miss a dose ?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose ?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, decreased appetite, constipation, confusion, and loss of consciousness.

What should I avoid while taking calcium gluconate ?

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect calcium gluconate ?

Calcium gluconate can make it harder for your body to absorb other medications you take by mouth. Tell your doctor if you are taking:

  • digoxin (Lanoxin, Lanoxicaps);
  • antacids or other calcium supplements;
  • calcitriol (Rocaltrol) or vitamin D supplements; or
  • doxycycline (Doryx, Oracea, Periostat, Vibramycin), minocycline (Dynacin, Minocin, Solodyn), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with calcium gluconate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about calcium gluconate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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