Drugs Details

Drugs Info of OptiPranolol
Drugs Details
  • Drugs Type  : FDA
  • Date : 9th Mar 2015 03:04 am
  • Brand Name : OptiPranolol
  • Generic Name : metipranolol ophthalmic (Pronunciation: MET i PRAN oh lol)
Descriptions

OptiPranolol® (metipranolol ophthalmic solution) 0.3% contains metipranolol, a non-selective beta-adrenergic receptor blocking agent. Metipranolol is a white, odorless, crystalline powder.

The chemical name of metipranolol is (± )-1-(4-Hydroxy-2, 3, 5-trimethylphenoxy)-3-(isopropylamino)-2-propanol-4-acetate.

The chemical structure of metipranolol is:

 

OptiPranolol® (metipranolol) Structural Formula Illustration

C17H27NO4             Mol. Wt. 309.40

 

Each mL of OptiPranolol® contains 3 mg of metipranolol. INACTIVES: Povidone, Glycerin, Hydrochloric Acid, Sodium Chloride, Edetate Disodium, and Purified Water. Sodium Hydroxide and/or Hydrochloric Acid may be added to adjust pH. The product is produced at pH 5.0-5.8 and osmolality 265 to 330 mOsmol/kg. PRESERVATIVE ADDED: Benzalkonium Chloride 0.004%.

 

What are the possible side effects of metipranolol ophthalmic (OptiPranolol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
  • drainage, crusting, or oozing of your eyes or eyelids;
  • vision changes, increased sensitivity of your eyes to light;
  • bronchospasm (wheezing, chest tightness, trouble...

Read All Potential Side Effects and See Pictures of Optipranolol »

What are the precautions when taking metipranolol ophthalmic solution (Optipranolol)?

Before using metipranolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e.g., timolol, levobunolol); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., asthma or a history of asthma, chronic obstructive pulmonary disease-COPD), certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (e.g.,...

Read All Potential Precautions of Optipranolol »

 

This monograph has been modified to include the generic and brand name in many instances.

Indications

OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open angle glaucoma.

Dosage Administration

The recommended dose is one drop of OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution in the affected eye(s) twice a day.

If the patient's IOP is not at a satisfactory level on this regimen, use of more frequent administration or a larger dose of OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution is not known to be of benefit. Concomitant therapy to lower intraocular pressure can be instituted.

In clinical trials, OptiPranolol® (metipranolol ophthalmic solution) Ophthalmic Solution was safely used during concomitant therapy with pilocarpine,epinephrine or acetazolamide.

 
 

How Supplied

OptiPranolol® (metipranolol ophthalmic solution) 0.3% is supplied in a plastic bottle with a controlled drop tip and a yellow plastic screw-top cap as follows:

5  mL: NDC 24208-275-07 - AB40207
10 mL: NDC 24208-275-09 - AB40209

Storage

Store between 15° - 30° C (59° - 86° F). Replace cap immediately after use.

DO NOT USE IF IMPRINTED NECKBAND IS NOT INTACT.

FOR OPHTHALMIC USE ONLY.

Bausch & Lomb Incorporated, Tampa, FL 33637. REV. 11/03-91. FDA rev date: 11/21/2006

In clinical trials, the use of OptiPranolol (metipranolol ophthalmic solution)Ophthalmic Solution has been associated with transient local discomfort.

Other ocular adverse reactions, such as abnormal vision, blepharitis, blurred vision, browache, conjunctivitis, edema, eyelid dermatitis, photophobia, tearing, and uveitis have been reported in small numbers of patients.

Other systemic adverse reactions, such as allergic reaction, angina, anxiety,arthritis, asthenia, atrial fibrillation, bradycardia, bronchitis, coughing,depression, dizziness, dyspnea, epistaxis, headache, hypertension, myalgia, myocardial infarct, nausea, nervousness, palpitation, rash, rhinitis, andsomnolence have also been reported in small numbers of patients.

Read the Optipranolol (metipranolol ophthalmic solution) Side Effects Center for a complete guide to possible side effects

Learn More »
 
 
 

This monograph has been modified to include the generic and brand name in many instances.

Side Effects

In clinical trials, the use of OptiPranolol (metipranolol ophthalmic solution)Ophthalmic Solution has been associated with transient local discomfort.

Other ocular adverse reactions, such as abnormal vision, blepharitis, blurred vision, browache, conjunctivitis, edema, eyelid dermatitis, photophobia, tearing, and uveitis have been reported in small numbers of patients.

Other systemic adverse reactions, such as allergic reaction, angina, anxiety,arthritis, asthenia, atrial fibrillation, bradycardia, bronchitis, coughing,depression, dizziness, dyspnea, epistaxis, headache, hypertension, myalgia, myocardial infarct, nausea, nervousness, palpitation, rash, rhinitis, andsomnolence have also been reported in small numbers of patients.

Read the Optipranolol (metipranolol ophthalmic solution) Side Effects Center for a complete guide to possible side effects

Learn More »
 
 
 

Interactions

OptiPranolol® (metipranolol ophthalmic solution) Ophthalmic Solution should be used with caution in patients who are receiving a beta-adrenergic blocking agent orally, because of the potential for additive effects on systemic beta-blockade.

Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production ofhypotension and/or bradycardia.

Caution should be used in the coadministration of beta-adrenergic receptorblocking agents, such as metipranolol, and oral or intravenous calcium channel antagonists, because of possible precipitation of left ventricularfailure, and hypotension. In patients with impaired cardiac function, who are receiving calcium channel antagonists, coadministration should be avoided.

The concomitant use of beta-adrenergic receptor blocking agents with digitalis and calcium channel antagonists may have additive effects, prolonging atrioventricular conduction time.

Caution should be used in patients using concomitant adrenergic psychotropic drugs.

Ocular

In patients with angle-closure glaucoma, the immediate treatment objective is to re-open the angle by constriction of the pupil with a miotic agent. OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution has little or no effect on the pupil, therefore, when it is used to reduce intraocular pressure in angle-closure glaucoma, it should be used only with concomitant administration of a miotic agent.

Read the Optipranolol Drug Interactions Center for a complete guide to possible interactions

Learn More »
 

This monograph has been modified to include the generic and brand name in many instances.

 
 

Warnings

As with other topically applied ophthalmic drugs, this drug may be absorbed systemically. Thus, the same adverse reactions found with systemicadministration of beta-adrenergic blocking agents may occur with topicaladministration. For example, severe respiratory reactions and cardiacreactions, including death due to bronchospasm in patients with asthma, and rarely, death in association with cardiac failure, have been reported following topical application of beta-adrenergic blocking agents (seeCONTRAINDICATIONS).

Since OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution had a minor effect on heart rate and blood pressure in clinical studies, caution should be observed in treating patients with a history of cardiac failure. Treatment with OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution should be discontinued at the first evidence of cardiac failure.

OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution, or other beta-blockers, should not, in general, be administered to patients withchronic obstructive pulmonary disease (e.g., chronic bronchitis, emphysema) of mild or moderate severity (see CONTRAINDICATIONS). However, if the drug is necessary in such patients, then it should be administered with caution since it may block bronchodilation produced by endogenous andexogenous catecholamine stimulation of beta2 receptors.

 
 

Precautions

General

Because of potential effects of beta-adrenergic receptor blocking agents relative to blood pressure and pulse, these agents should be used with caution in patients with cerebrovascular insufficiency. If signs or symptoms suggesting reduced cerebral blood flow develop following initiation of therapywith OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution, alternative therapy should be considered.

Some authorities recommend gradual withdrawal of beta-adrenergic receptor blocking agents in patients undergoing elective surgery. If necessary during surgery, the effects of beta-adrenergic receptor blocking agents may be reversed by sufficient doses of such agonists as isoproterenol, dopamine, dobutamine or levarterenol.

While OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution has demonstrated a low potential for systemic effect, it should be used with caution in patients with diabetes (especially labile diabetes) because of possible masking of signs and symptoms of acute hypoglycemia.

Beta-adrenergic receptor blocking agents may mask certain signs and symptoms of hyperthyroidism, and their abrupt withdrawal might precipitate athyroid storm.

Beta-adrenergic blockade has been reported to potentiate muscle weakness consistent with certain myasthenic symptoms (e.g., diplopia, ptosis, and generalized weakness).

Risk of anaphylactic reaction: While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Lifetime studies with metipranolol have been conducted in mice at oral doses of 5, 50, and 100 mg/kg/day and in rats at oral doses of up to 70 mg/kg/day. Metipranolol demonstrated no carcinogenic effect. In the mouse study, female animals receiving the low, but not the intermediate or high dose, had an increased number of pulmonary adenomas. The significance of this observation is unknown. In a variety of in vitro and in vivo bacterial and mammalian cell assays, metipranolol was nonmutagenic.

Reproduction and fertility studies of metipranolol in rats and mice showed noadverse effect on male fertility at oral doses of up to 50 mg/kg/day, and female fertility at oral doses of up to 25 mg/kg/day.

Pregnancy-Teratogenic effects

Pregnancy Category C

No drug related effects were reported for the segment II teratology study in fetal rats after administration, during organogenesis, to dams of up to 50 mg/kg/day. OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution has been shown to increase fetal resorption, fetal death, and delayed development when administered orally to rabbits at 50 mg/kg/day during organogenesis.

There are no adequate and well-controlled studies in pregnant women. OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

It is not known whether OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution is administered to nursing women.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatric Use

No overall differences in safety or effectiveness have been observed between elderly and younger patients.

This monograph has been modified to include the generic and brand name in many instances.

OverDose

No information is available on overdosage of OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution in humans. The symptoms which might be expected with an overdose of a systemically administered beta-adrenergic receptor blocking agent are bradycardia, hypotension and acutecardiac failure.

 
 

ContrainDications

Hypersensitivity to any component of this product.

OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution is contraindicated in patients with bronchial asthma or a history of bronchial asthma, or severe chronic obstructive pulmonary disease; symptomatic sinus bradycardia; greater than a first degree atrioventricular block; cardiogenicshock; or overt cardiac failure.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

Metipranolol blocks beta1 and beta2 (non-selective) adrenergic receptors. It does not have significant intrinsic sympathomimetic activity, and has only weak local anesthetic (membrane-stabilizing) and myocardial depressant activity.

Orally administered beta-adrenergic blocking agents reduce cardiac outputin both healthy subjects and patients with heart disease. In patients with severe impairment of myocardial function, beta-adrenergic receptorantagonists may inhibit the sympathetic stimulatory effect necessary to maintain adequate cardiac output.

Beta-adrenergic receptor blockade in the bronchi and bronchioles may result in significantly increased airway resistance from unopposed parasympathetic activity. Such an effect is potentially dangerous in patients with asthma or other bronchospastic conditions (see CONTRAINDICATIONS andWARNINGS).

OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution, when applied topically in the eye, has the action of reducing elevated as well as normal intraocular pressure (IOP), whether or not accompanied byglaucoma. Elevated intraocular pressure is a major risk factor in thepathogenesis of glaucomatous visual field loss. The higher the level of intraocular pressure, the greater the likelihood of glaucomatous visual field loss and optic nerve damage.

The primary mechanism of the ocular hypotensive action of metipranolol is most likely due to a reduction in aqueous humor production. A slight increase in outflow may be an additional mechanism. OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution reduces IOP with little or no effect on pupil size or accommodation.

In controlled studies of patients with intraocular pressure greater than 24 mmHg at baseline, OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution reduced the average intraocular pressure approximately 20-26%.

The onset of action of OptiPranolol (metipranolol ophthalmic solution) Ophthalmic Solution, as measured by a reduction in intraocular pressure, occurs within 30 minutes after a single administration. The maximum effect occurs at about 2 hours. A reduction in intraocular pressure can be demonstrated 24 hours after a single dose. Clinical studies in patients with glaucoma treated for up to two years indicate that an intraocular pressure lowering effect is maintained.

Animal pharmacology

In rabbits administered metipranolol in one eye at 2 to 4 fold increased concentrations, multi-focal interstitial nephritis was observed in male animals, and lympho-hystiocytic and heterophilic interstitial pneumonia was observed in female animals. The clinical relevance of these findings is unknown.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

Patients should be instructed to avoid allowing the tip of the dispensing container to contact the eye or surrounding structures.

Patients should be advised that OptiPranolol (metipranolol ophthalmic solution) contains benzalkonium chloride which may be absorbed by soft contact lenses. Contact lenses should be removed prior to administration of the solution. Lenses may be reinserted 15 minutes following OptiPranolol (metipranolol ophthalmic solution) administration.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

 

METIPRANOLOL - OPHTHALMIC

 

(met-eh-PRAN-oh-lol)

 

COMMON BRAND NAME(S): Optipranolol

 

USES: This medication is used alone or with other medications to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (e.g., ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness. Metipranolol belongs to a class of drugs known as beta blockers and works by decreasing the amount of fluid production within the eye.

 

HOW TO USE: To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

If you are wearing contact lenses, remove them before using eye drops. Wait at least 15 minutes before replacing your contact lenses.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch, usually twice daily or as directed by your doctor. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 to 10 minutes before using the other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. It is important to continue using this medication even if you feel well. Most people with glaucoma or high pressure in the eyes do not feel sick.

Consumer Overview Side Effect

SIDE EFFECTS: Temporary discomfort of the eye, blurred vision, watery eyes, headache, drowsiness, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain/swelling/discharge, increased eye sensitivity to light, vision changes, slow/irregular heartbeat, muscle weakness, mental/mood changes, tiredness, swelling of the ankles/feet, sudden/unexplained weight gain.

Seek immediate medical attention if any of these rare but very serious side effects occur: trouble breathing, chest/jaw/left arm pain, weakness on one side of the body, slurred speech, confusion.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

 

Read the Optipranolol (metipranolol ophthalmic solution) Side Effects Center for a complete guide to possible side effects

Learn More »
 

PRECAUTIONS: Before using metipranolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e.g., timolol, levobunolol); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., asthma or a history of asthma, chronic obstructive pulmonary disease-COPD), certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (e.g., cardiogenic shock, severe heart failure).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., bronchitis, emphysema), diabetes, heart failure (treated, stable type), blood circulation problems (e.g., cerebrovascular insufficiency), overactive thyroid (hyperthyroidism), muscle weakness disorders (e.g., myasthenia gravis).

Before having surgery, tell your doctor or dentist that you are using this medication.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

If you have diabetes, this product may mask the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level, such as dizziness/sweating, are unaffected by this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

 

 

 

Consumer Overview Missed Dose

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: certain psychiatric drugs (e.g., venlafaxine, tricyclic antidepressants such as amitriptyline), digoxin, drugs for high blood pressure (e.g., clonidine, reserpine, oral beta blockers such as propranolol, calcium channel blockers such as diltiazem), epinephrine, fingolimod.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

 

OVERDOSE: This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. If this product is accidentally swallowed, you may experience symptoms such as trouble breathing, slow/irregular heartbeat.

 

NOTES: Do not share this medication with others.

Laboratory and/or medical tests (e.g., eye exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

 

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

 

STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.

Patient Detailed Side Effect

Brand Names: OptiPranolol

Generic Name: metipranolol ophthalmic (Pronunciation: MET i PRAN oh lol)

  • What is metipranolol ophthalmic (Optipranolol)?
  • What are the possible side effects of metipranolol ophthalmic (Optipranolol)?
  • What is the most important information I should know about metipranolol ophthalmic (Optipranolol)?
  • What should I discuss with my healthcare provider before using metipranolol ophthalmic (Optipranolol)?
  • How should I use metipranolol ophthalmic (Optipranolol)?
  • What happens if I miss a dose (Optipranolol)?
  • What happens if I overdose (Optipranolol)?
  • What should I avoid while using metipranolol ophthalmic (Optipranolol)?
  • What other drugs will affect metipranolol ophthalmic (Optipranolol)?
  • Where can I get more information?

What is metipranolol ophthalmic (Optipranolol)?

 

Metipranolol is a beta-blocker that reduces pressure inside the eye.

Metipranolol ophthalmic (for the eyes) is used to treat open-angle glaucoma and other causes of high pressure inside the eye.

Metipranolol ophthalmic may also be used for other purposes not listed in this medication guide.

What are the possible side effects of metipranolol ophthalmic (Optipranolol)?

 

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
  • drainage, crusting, or oozing of your eyes or eyelids;
  • vision changes, increased sensitivity of your eyes to light;
  • bronchospasm (wheezing, chest tightness, trouble breathing);
  • sudden numbness or weakness, headache, confusion, problems with vision, speech, or balance;
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
  • feeling short of breath, even with mild exertion; or
  • swelling, rapid weight gain.

Less serious side effects may include:

  • mild watering or discomfort of your eyes;
  • blurred vision;
  • mildly swollen or puffy eyes;
  • headache, dizziness, drowsiness;
  • sleep problems (insomnia);
  • muscle weakness; or
  • altered sense of taste or smell.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Optipranolol (metipranolol ophthalmic solution) Side Effects Center for a complete guide to possible side effects

Learn More »
 

What is the most important information I should know about metipranolol ophthalmic (Optipranolol)?

 

Do not use this medication if you are allergic to metipranolol, or if you have asthma, or severe chronic obstructive pulmonary disease (COPD), slow heartbeats, or a heart condition called "AV block."

Before using this medication, tell your doctor if you have breathing problems such as bronchitis or emphysema, a history of heart disease or congestive heart failure, diabetes, history of stroke, blood clot, or circulation problems, a thyroid disorder, or a muscle disorder such as myasthenia gravis.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Metipranolol ophthalmic is sometimes given together with other eye medications. Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using metipranolol ophthalmic. Do not use the medications at the same time.

Metipranolol ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Do not use this medication while you are wearing contact lenses. Metipranolol ophthalmic may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using metipranolol before putting your contact lenses in.

Side Effects Centers
  • Optipranolol

Patient Detailed How Take

What should I discuss with my healthcare provider before using metipranolol ophthalmic (Optipranolol)?

 

Do not use this medication if you are allergic to metipranolol, or if you have:

  • asthma, or severe chronic obstructive pulmonary disease (COPD);
  • slow heartbeats; or
  • a heart condition called "AV block."

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • breathing problems such as bronchitis or emphysema;
  • a history of heart disease or congestive heart failure;
  • diabetes;
  • history of stroke, blood clot, or circulation problems;
  • a thyroid disorder; or
  • a muscle disorder such as myasthenia gravis.

FDA pregnancy category C. It is not known whether metipranolol ophthalmic is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether metipranolol passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use metipranolol ophthalmic (Optipranolol)?

 

Use metipranolol ophthalmic exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Wash your hands before using the eye drops.

Do not use this medication while you are wearing contact lenses. Metipranolol ophthalmic may contain a preservative that can be absorbed by soft contact lenses. Wait at least 15 minutes after using metipranolol before putting your contact lenses in.

To apply the eye drops:

  • Tilt your head back slightly and pull down your lower eyelid. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.
  • Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.
  • Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

Tell your doctor right away if you have any eye injury or infection. If you have any type of surgery, tell the surgeon ahead of time that you are using metipranolol ophthalmic. You may need to stop using the medicine for a short time.

Store this medication at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Side Effects Centers
  • Optipranolol

Patient Detailed Avoid Taking

What happens if I miss a dose (Optipranolol)?

 

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose (Optipranolol)?

 

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include slow heart rate, feeling short of breath, swelling, rapid weight gain, or fainting.

What should I avoid while using metipranolol ophthalmic (Optipranolol)?

 

Metipranolol ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Metipranolol ophthalmic is sometimes given together with other eye medications. Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using metipranolol ophthalmic. Do not use the medications at the same time.

What other drugs will affect metipranolol ophthalmic (Optipranolol)?

 

Before using metipranolol ophthalmic, tell your doctor if you are using any of the following drugs:

  • digoxin (digitalis, Lanoxin);
  • reserpine;
  • insulin or diabetes medications you take by mouth;
  • any other beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), timolol (Blocadren), and others;
  • a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan); or
  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), or thioridazine (Mellaril).

This list is not complete and there may be other drugs that can interact with metipranolol ophthalmic. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

 

Your pharmacist can provide more information about metipranolol ophthalmic.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 7.02. Revision date: 12/15/2010.

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