Drugs Details

Drugs Info of Carbachol Ophthalmic, Isopto Carbachol, Miostat
Drugs Details
  • Drugs Type  : FDA
  • Date : 16th Mar 2015 04:44 am
  • Brand Name : Carbachol Ophthalmic, Isopto Carbachol, Miostat
  • Generic Name : carbachol ophthalmic (Pronunciation: KAR ba kall)
Descriptions

MIOSTAT® (carbachol intraocular solution, USP) is a sterile balanced salt solution of carbachol for intraocular injection. The active ingredient is represented by the chemical structure:

 

MIOSTAT® (carbachol) Structural formula Illustration

 

Established name: Carbachol

Chemical name: Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride.

Molecular Formula: C6H15CIN2O2

Molecular Weight: 182.65

Each mL contains: Active: carbachol 0.01%. Inactives: sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride dihydrate 0.048%, magnesium chloride hexahydrate 0.03%, sodium acetate trihydrate 0.39%, sodium citrate dihydrate 0.17%, sodium hydroxide and/or hydrochloric acid (to adjust pH) and Water for Injection. pH range is 6.5-7.5.

 

What are the possible side effects of carbachol ophthalmic (Carbachol Ophthalmic, Isopto Carbachol, Miostat)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • vision problems, seeing "floaters" in your vision;
  • feeling like you might pass out;
  • fast or slow heartbeats;
  • wheezing, trouble breathing; or
  • severe burning, stinging, or eye irritation after using the eye drops;

Less serious side effects may...

Read All Potential Side Effects and See Pictures of Miostat »

 

This monograph has been modified to include the generic and brand name in many instances.

Indications

Intraocular use for obtaining miosis during surgery. In addition, MIOSTAT (carbachol intraocular solution, USP) reduces the intensity of intraocular pressure elevation in the first 24 hours after cataract surgery.

Dosage Administration

Aseptically remove the sterile vial from the blister package by peeling the backing paper and dropping the vial onto a sterile tray. Withdraw the contents into a dry sterile syringe, and replace the needle with an atraumaticcannula prior to intraocular instillation. No more than one-half milliliter should be gently instilled into the anterior chamber for the production of satisfactory miosis. It may be instilled before or after securing sutures. Miosis is usually maximal within two to five minutes after application.

How Supplied

In a 2.0 mL glass vial with a 1.5 mL fill, grey butyl stopper and aluminum seal packaged twelve to a carton.

NDC 0065-0023-15

Storage: Store at 15°-30°C (59°-86° F).

Alcon Laboratories, Inc., Fort Worth, Texas 76134, USA. Revised: December 2003. FDA Rev date: 11/10/2004

This monograph has been modified to include the generic and brand name in many instances.

 
 

Side Effects

Ocular:Corneal clouding, persistent bullous keratopathy, retinal detachmentand postoperative iritis following cataract extraction have been reported.

Systemic: Side effects such as flushing, sweating, epigastric distress, abdominal cramps, tightness in urinary bladder, and headache have been reported with topical or systemic application of carbachol.

Read the Miostat (carbachol intraocular solution) Side Effects Centerfor a complete guide to possible side effects

Learn More »
 
 
 

Interactions

No information provided.

Read the Miostat Drug Interactions Center for a complete guide to possible interactions

Learn More »
 

This monograph has been modified to include the generic and brand name in many instances.

Warnings

For single-dose intraocular use only. Discard unused portion. Intraocular carbachol 0.01 % should be used with caution in patients with acute cardiac failure, bronchial asthma, peptic ulcer, hyperthyroidism, G.I. spasm, urinary tract obstruction and Parkinson's disease.

Precautions

Use only if the container is undamaged.

Carcinogenesis: Studies in animals to evaluate the carcinogenic potential have not been conducted.

Pregnancy: Category C. There are no adequate and well-controlled studies in pregnant women. MIOSTAT® (carbachol intraocular solution, USP) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing mothers: It is not known if this medication is excreted in breast milk. Exercise caution when administering to a nursing woman.

Pediatric Use: Safety and efficacy in pediatric patients have not been established.

Geriatric Use: No overall differences in safety or effectiveness have been observed between elderly and younger patients.

This monograph has been modified to include the generic and brand name in many instances.

OverDose

No information provided.

ContrainDications

Should not be used in those persons showing hypersensitivity to any of the components of this preparation.

This monograph has been modified to include the generic and brand name in many instances.

Clinical Pharamacology

Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known.

This monograph has been modified to include the generic and brand name in many instances.

Patient Information

No information provided. Please refer to the WARNINGS andPRECAUTIONS sections.

This monograph has been modified to include the generic and brand name in many instances.

Consumer Overview Uses

No Information Available!

Consumer Overview Side Effect

No Information Available!

Consumer Overview Missed Dose

No Information Available!

Patient Detailed Side Effect

Brand Names: Carbachol Ophthalmic, Isopto Carbachol, Miostat

Generic Name: carbachol ophthalmic (Pronunciation: KAR ba kall)

  • What is carbachol ophthalmic (Miostat)?
  • What are the possible side effects of carbachol ophthalmic (Miostat)?
  • What is the most important information I should know about carbachol ophthalmic (Miostat)?
  • What should I discuss with my healthcare provider before using carbachol ophthalmic (Miostat)?
  • How should I use carbachol ophthalmic (Miostat)?
  • What happens if I miss a dose (Miostat)?
  • What happens if I overdose (Miostat)?
  • What should I avoid while using carbachol ophthalmic (Miostat)?
  • What other drugs will affect carbachol ophthalmic (Miostat)?
  • Where can I get more information?

What is carbachol ophthalmic (Miostat)?

 

Carbachol lowers pressure in the eye by increasing the amount of fluid that drains from the eye.

Carbachol ophthalmic (for the eye) is used to treat glaucoma.

Carbachol ophthalmic may also be used for purposes not listed in this medication guide.

What are the possible side effects of carbachol ophthalmic (Miostat)?

 

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • vision problems, seeing "floaters" in your vision;
  • feeling like you might pass out;
  • fast or slow heartbeats;
  • wheezing, trouble breathing; or
  • severe burning, stinging, or eye irritation after using the eye drops;

Less serious side effects may include:

  • headache;
  • stomach cramps, vomiting;
  • diarrhea;
  • mild eye irritation; or
  • increased sweating or urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Miostat (carbachol intraocular solution) Side Effects Center for a complete guide to possible side effects

Learn More »
 

What is the most important information I should know about carbachol ophthalmic (Miostat)?

 

You should not use carbachol if you are allergic to it, or if you have swelling of your iris (the colored part of your eye).

Before using this medication, tell your doctor if you have had a recent eye injury, heart failure or recent heart attack, high or low blood pressure, asthma, a stomach ulcer, an overactive thyroid, urination problems, Parkinson's disease, if you have had a retinal tear, if you are nearsighted, or if you have had cataract surgery.

Do not allow the tip of the dropper to touch any surface, including your eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Do not use this medication while wearing contact lenses. Carbachol ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using carbachol before putting in your contact lenses.

Call your doctor at once if you have vision problems, seeing "floaters" in your vision, or severe burning, stinging, or if you have eye irritation after using the eye drops.

Side Effects Centers
  • Miostat

Patient Detailed How Take

What should I discuss with my healthcare provider before using carbachol ophthalmic (Miostat)?

 

You should not use carbachol if you are allergic to it, or if you have swelling of your iris (the colored part of your eye).

To make sure this medication is safe for you, tell your doctor if you have any of these other conditions:

  • heart failure or recent heart attack;
  • high or low blood pressure;
  • asthma;
  • a stomach ulcer;
  • an overactive thyroid;
  • urination problems;
  • Parkinson's disease; or
  • if you have had a recent eye injury, a retinal tear, if you are nearsighted, or if you have had cataract surgery.

FDA pregnancy category C. It is not known whether carbachol ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether carbachol ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use carbachol ophthalmic (Miostat)?

 

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Wash your hands before using eye medication.

To apply the eye drops:

  • Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.
  • Use only the number of drops your doctor has prescribed.
  • Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct.
  • If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.
  • Also wait at least 10 minutes before using any other eye drops that your doctor has prescribed.

Do not allow the tip of the dropper to touch any surface, including your eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medication.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

Side Effects Centers
  • Miostat

Patient Detailed Avoid Taking

What happens if I miss a dose (Miostat)?

 

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose (Miostat)?

 

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using carbachol ophthalmic (Miostat)?

 

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Do not use this medication while wearing contact lenses. Carbachol ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using carbachol before putting in your contact lenses.

Do not use other eye medications during treatment with carbachol unless your doctor tells you to.

What other drugs will affect carbachol ophthalmic (Miostat)?

 

It is not likely that other drugs you take orally or inject will have an effect on carbachol used in the eyes. But many drugs can interact with each other. Tell your doctor about all medicines you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

 

Your pharmacist can provide more information about carbachol ophthalmic.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 6.01. Revision date: 10/15/2012.

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