Drugs Details

Drugs Info of Vectical
Drugs Details
  • Drugs Type  : Multum
  • Date : 25th Jun 2015 03:06 am
  • Brand Name : Vectical
  • Generic Name : calcitriol (topical) (Pronunciation: kal SIT ree ol TOP ik al)
Descriptions

VECTICAL (calcitriol) Ointment 3 mcg/g is a vitamin D analog intended for topical application to the skin. The chemical name of the active ingredient is (5Z,7E)-9,10­ secocholesta-5,7,10(19)-triene-α,3β,25-triol. The structural formula is:

 

VECTICAL (calcitriol) Structural Formula Illustration

Calcitriol is a white or almost white crystalline solid. It is practically insoluble in water, soluble in alcohol and in fatty oils. The molecular formula is C27H44O3, and the molecular weight is 416.64.

VECTICAL (calcitriol ointment) Ointment is a translucent ointment containing 3 mcg/g (0.0003% w/w) of calcitriol, packaged in aluminum tubes with screw caps. Other components of the ointment are mineral oil, dl-α-tocopherol, and white petrolatum.

What are the possible side effects of calcitriol topical (Vectical)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using calcitriol topical and call your doctor at once if you have any of these serious side effects:

  • blistering, or severe redness, itching, or other irritation of treated areas; or
  • worsened symptoms or no improvement in psoriasis.

Using calcitriol topical can affect your body's ability to metabolize calcium. This can result in high levels of calcium in your blood...

Read All Potential Side Effects and See Pictures of Vectical Ointment »

What are the precautions when taking calcitriol ointment (Vectical Ointment)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high calcium/vitamin D levels (hypercalcemia/hypervitaminosis D), kidney disease, liver disease.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. Your doctor may direct you to limit or avoid phototherapy while you use this medication. Discuss this further with your doctor.

During...

Read All Potential Precautions of Vectical Ointment »

 

Indications

Indication

VECTICAL (calcitriol ointment) Ointment is indicated for the topical treatment of mild to moderate plaque psoriasis in adults 18 years and older.

Limitations of Use

VECTICAL (calcitriol ointment) Ointment should not be applied to the eyes, lips, or facial skin.

Dosage Administration

Apply VECTICAL (calcitriol ointment) Ointment to affected areas twice daily, morning and evening. The maximum weekly dose should not exceed 200 grams. VECTICAL (calcitriol ointment) Ointment is not for oral, ophthalmic or intravaginal use.

How Supplied

Dosage Forms And Strengths

Each gram of ointment contains 3 micrograms (mcg/g) of calcitriol.

Storage And Handling

VECTICAL (calcitriol ointment) Ointment 3 mcg/g is available in collapsible aluminum tubes of the following package sizes:

  • 5 g tube (NDC 0299-2012-05)
  • 100 g tube (NDC 0299-2012-10)

Storage

Store at 25° C (77° F); excursions permitted to 15° - 30° C (59° - 86° F) [See USP Controlled Room Temperature.] Do not freeze or refrigerate.

Marketed by: Galderma Laboratories L.P., Fort Worth, Texas 76177. Manufactured by: Galderma Production Canada, Inc., Baie d'Urfé, QC H9X 3S4, Canada. Made in Canada.

Side Effects

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.

Clinical Studies Experience

VECTICAL (calcitriol ointment) Ointment was studied in two vehicle-controlled studies (419 subjects), and in one open label study (324 subjects). The table below describes exposure to VECTICAL (calcitriol ointment) Ointment in 743 subjects, including 239 exposed for 6 months and 116 exposed for one year.

Four hundred and nineteen subjects were treated with VECTICAL (calcitriol ointment) Ointment twice daily for 8 weeks. The population included subjects ages 13 to 87, males (284) and females (135), Caucasians (372) and non-Caucasians (47); with mild (105) to moderate (313) chronic plaque psoriasis.

Selected Adverse Events Occurring in at least 1% of Subjects in the Two Pooled Vehicle-Controlled Studies

  Vectical Ointment
(n=419)
Vehicle Ointment
(n=420)
Discomfort skin 3% 2%
Pruritus 1% 1%

Among subjects having laboratory monitoring, hypercalcemia was observed in 24% (18/74) of subjects exposed to active drug and in 16% (13/79) of subjects exposed to vehicle, however the elevations were less than 10% above the upper limit of normal [see WARNINGS AND PRECAUTIONS]

The open label study enrolled 324 subjects with psoriasis who were then treated for up to 52 weeks. Adverse events reported at a rate of greater than or equal to 3% of subjects treated with VECTICAL (calcitriol ointment) Ointment were lab test abnormality (8%), urine abnormality (4%), psoriasis (4%), hypercalciuria (3%), and pruritus (3%). Kidney stones were reported in 3 subjects and confirmed in two.

Postmarketing Experience

The following adverse reactions have been identified during world-wide post-approval use of VECTICAL (calcitriol ointment) Ointment: acute blistering dermatitis, erythema, pruritus, skin burning sensation, and skin discomfort. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Read the Vectical Ointment (calcitriol ointment) Side Effects Center for a complete guide to possible side effects

Interactions

VECTICAL (calcitriol ointment) Ointment should be used with caution in patients receiving medications known to increase the serum calcium level, such as thiazide diuretics. Caution should also be exercised in patients receiving calcium supplements or high doses of vitamin D [see WARNINGS AND PRECAUTIONS].

Read the Vectical Ointment Drug Interactions Center for a complete guide to possible interactions

Warnings

Included as part of the PRECAUTIONS section.

Precautions

Effects on Calcium Metabolism

In controlled clinical trials with VECTICAL (calcitriol ointment) Ointment, among subjects having laboratory monitoring, hypercalcemia was observed in 24% (18/74) of subjects exposed to active drug and in 16% (13/79) of subjects exposed to vehicle. However, the increases in calcium and albumin-adjusted calcium levels were less than 10% above the upper limit of normal.

If aberrations in parameters of calcium metabolism occur, treatment should be discontinued until these parameters have normalized. The effects of VECTICAL (calcitriol ointment) Ointment on calcium metabolism following treatment durations greater than 52 weeks have not been evaluated. Increased absorption may occur with occlusive use.

Ultraviolet Light Exposure

Animal data suggest that the vehicle of VECTICAL (calcitriol ointment) Ointment may enhance the ability of ultraviolet radiation (UVR) to induce skin tumors [see Carcinogenesis, Mutagenesis, Impairment of Fertility]

Subjects who apply VECTICAL (calcitriol ointment) Ointment to exposed skin should avoid excessive exposure of the treated areas to either natural or artificial sunlight, including tanning booths and sun lamps. Physicians may wish to limit or avoid use of phototherapy in patients who use VECTICAL (calcitriol ointment) Ointment.

Unevaluated Uses

The safety and effectiveness of VECTICAL (calcitriol ointment) Ointment in patients with known or suspected disorders of calcium metabolism have not been evaluated.

The safety and effectiveness of VECTICAL (calcitriol ointment) Ointment in patients with erythrodermic, exfoliative, or pustular psoriasis have not been evaluated.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

When calcitriol was applied topically to mice for up to 24 months, no significant changes in tumor incidence were observed. Concentrations of calcitriol in ointment base of 0 (vehicle control), 0.3, 0.6 and 1.0 ppm were evaluated.

A two-year carcinogenicity study was conducted in which calcitriol was orally administered to rats at dosages of approximately 0.005, 0.03, and 0.1 mcg/kg/day (0.03, 0.18, and 0.6 mcg/m²/day, respectively). The incidence of benign pheochromocytomas was significantly increased in female rats. No other significant differences in tumor incidence data were observed.

In a study in which albino hairless mice were exposed to both ultra-violet radiation (UVR) and topically applied calcitriol ointment, a reduction in the time required for UVR to induce the formation of skin tumors was observed in all groups that received the ointment base, including the vehicle-treated control group, relative to animals that received no ointment but which were exposed to UVR. The time required for UVR to induce the formation of skin tumors did not differ between animals that received plain vehicle and those that received vehicle that contained calcitriol. Concentrations of calcitriol in ointment base of 0 (vehicle control), 0.3, 0.6 and 1.0 ppm were evaluated. These data suggest that the vehicle of VECTICAL (calcitriol ointment) Ointment may enhance the ability of UVR to induce skin tumors.

Calcitriol did not elicit genotoxic effects in the mouse lymphoma TK locus assay. Studies in which male and female rats received oral doses of calcitriol of up to 0.6 mcg/kg/day (3.6 mcg/m²/day) indicated no impairment of fertility or general reproductive performance. Based upon the recommended human dose and instructions for use, it is not possible to calculate human dose equivalents for animal exposure in these studies.

Use In Specific Populations

Pregnancy

Teratogenic Effects: Pregnancy Category C.

VECTICAL Ointment contains calcitriol which has been shown to be fetotoxic. There are no adequate and well-controlled studies for VECTICAL (calcitriol ointment) Ointment in pregnant women. VECTICAL (calcitriol ointment) Ointment should be used during pregnancy only if the potential benefit to the patient justifies the potential risk to the fetus.

Teratogenicity studies with calcitriol were performed in which rats were treated orally at dosages up to 0.9 mcg/kg/day (5.4 mcg/m²/day) and in which rabbits received topical application of calcitriol ointment (3 ppm) to 6.4% of the body surface area. No effects on reproductive or fetal parameters were observed in rats. In rabbits, topically applied calcitriol induced a significantly elevated mean post-implantation loss and an increased incidence of minor skeletal abnormalities due to retarded ossification of the pubic bones. A slightly increased incidence of skeletal variation (extra 13thrib, reduced ossification of epiphyses) was also observed. These effects may have been secondary to maternal toxicity. Based on the recommended human dose and instructions for use, it is not possible to calculate human dose equivalents for animal exposures in these studies.

Nursing Mothers

It is not known whether calcitriol is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when VECTICAL (calcitriol ointment) Ointment is administered to a nursing woman.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatric Use

Clinical studies of VECTICAL (calcitriol ointment) Ointment did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported experience has not identified differences in responses between the elderly and younger patients.


This monograph has been modified to include the generic and brand name in many instances.

OverDose

Topically applied calcitriol can be absorbed in sufficient amounts to produce systemic effects [see WARNINGS AND PRECAUTIONS]

ContrainDications

None

Clinical Pharamacology

The contribution to efficacy of individual components of the vehicle has not been established.

Mechanism of Action

The mechanism of action of calcitriol in the treatment of psoriasis has not been established.

Pharmacokinetics

The systemic exposure of calcitriol was assessed in subjects with chronic, plaque psoriasis. In the pivotal pharmacokinetic/pharmacodynamic study, calcitriol ointment 3 mcg/g, was applied twice daily for 21 days (for a total dose of 30 g/day) to 35% of the body surface area (psoriatic + surrounding healthy skin) of subjects with at least 25% of body surface area involvement. At Day 21, the geometric mean plasma concentration values of Cmax increased by approximately 36% over baseline and the geometric mean value of AUC(0 – 12 hr) increased by 44%. There was no correlation between the elevated calcitriol levels and the pharmacodynamic parameters of serum albumin adjusted calcium, serum phosphorus, urinary calcium and urinary phosphorus.

Clinical Studies

In two, multicenter, double-blind, vehicle-controlled studies, a total of 839 subjects with psoriasis rated “mild” or “moderate” using an investigator global assessment scale were treated twice daily for 8 weeks. Subjects were randomized in a 1:1 ratio to receive either VECTICAL (calcitriol ointment) Ointment or vehicle ointment. The mean age of the subjects was 48 years and 66% were male; most subjects were rated “moderate” at baseline.

Success was defined as “Clear or Minimal”(up to light red or pink in coloration, surface dryness with some white coloration, and slight elevation above normal skin) with at least a 2-grade change from baseline. The success rates are displayed in the table.

Percentage of Subjects with Clear or Minimal Disease AND Two Grade Improvement at End of Treatment (8 weeks)

 

Study 1 Study 2
VECTICAL Ointment
(N=209)
Vehicle Ointment
(N=209)
VECTICAL Ointment
(N=210)
Vehicle Ointment
(N=211)
23.4% 14.4% 20.5% 6.6%

 

Patient Information

This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

Patients using VECTICAL (calcitriol ointment) Ointment should receive the following information:

Instructions for Use

This medication is to be used as directed by the physician. It is for external use only. This medication is to be applied only to areas of the skin affected by psoriasis, as directed. It should be gently rubbed into the skin so that no medication remains visible.

Adverse Reactions

Patients should report any signs of adverse reactions to their physician.

Consumer Overview Uses

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

 

CALCITRIOL OINTMENT - TOPICAL

 

(KAL-si-TRYE-ol)

 

COMMON BRAND NAME(S): Vectical

 

USES: This medication is used to treat psoriasis. Calcitriol is a form of vitamin D. It works by slowing down the growth of cells.

 

HOW TO USE: Use this medication on the skin only. Wash the affected area and pat dry. Apply a thin layer of medication usually twice daily, in the morning and in the evening, or as directed by your doctor. Apply only to the areas of skin affected by psoriasis. Gently rub in. Wash your hands after using, unless you are using this medication to treat the hands. Do not apply calcitriol to the face, in the eyes, nose, or mouth, or inside the vagina. If you do get the medication in those areas, flush with plenty of water.

Do not apply to a larger area of skin, apply more often, or use longer than prescribed. Your skin will not improve any faster and this may increase the risk of side effects. Do not cover, bandage, or wrap the area unless directed to do so by your doctor. Do not apply to more than one-third of your body. Do not use more than 1 ounce (30 grams) daily.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.

Inform your doctor if your condition does not improve or if it worsens. You should usually begin to see an improvement in your skin condition after 4 weeks of treatment.

Consumer Overview Side Effect

SIDE EFFECTS: Pain, burning, itching, redness, or peeling at the application site may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may rarely increase calcium in your blood. Tell your doctor immediately if any of these symptoms of high calcium occur: unusual tiredness, mental/mood changes, unexplained constipation, pink/bloody urine, painful urination.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

 

Read the Vectical Ointment (calcitriol ointment) Side Effects Center for a complete guide to possible side effects

Learn More »

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high calcium/vitamin D levels (hypercalcemia/hypervitaminosis D), kidney disease, liver disease.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. Your doctor may direct you to limit or avoid phototherapy while you use this medication. Discuss this further with your doctor.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Consumer Overview Missed Dose

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other products containing vitamin D, drugs that can increase calcium levels (such as thiazide "water pills", calcium supplements).

Calcitriol ointment may be irritating to the skin. Ask your doctor or pharmacist about the safe use of other skin products that may have a drying effect (such as astringents, peeling agents).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

 

OVERDOSE: This medication may be harmful if applied to large areas or swallowed. If overdose or swallowing is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, loss of appetite, muscle weakness, depression.

 

NOTES: Do not share this medication with others.

Laboratory and/or medical tests (such as calcium levels) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

This medication has been prescribed for your current condition only. Do not use it later for another skin condition unless told to do so by your doctor. A different medication may be necessary in that case.

 

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

 

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not freeze or refrigerate. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.

Patient Detailed Side Effect

Brand Names: Vectical

Generic Name: calcitriol (topical) (Pronunciation: kal SIT ree ol TOP ik al)

  • What is calcitriol topical (Vectical Ointment)?
  • What are the possible side effects of calcitriol topical (Vectical Ointment)?
  • What is the most important information I should know about calcitriol topical (Vectical Ointment)?
  • What should I discuss with my healthcare provider before using calcitriol topical (Vectical Ointment)?
  • How should I use calcitriol topical (Vectical Ointment)?
  • What happens if I miss a dose (Vectical Ointment)?
  • What happens if I overdose (Vectical Ointment)?
  • What should I avoid while using calcitriol topical (Vectical Ointment)?
  • What other drugs will affect calcitriol topical (Vectical Ointment)?
  • Where can I get more information?

What is calcitriol topical (Vectical Ointment)?

Calcitriol is a form of vitamin D. It works by decreasing the rate of skin cell reproduction.

Calcitriol topical (for the skin) is used to treat plaque psoriasis (raised, silvery flaking of the skin) in adults.

Calcitriol topical may also be used for purposes not listed in this medication guide.

What are the possible side effects of calcitriol topical (Vectical Ointment)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using calcitriol topical and call your doctor at once if you have any of these serious side effects:

  • blistering, or severe redness, itching, or other irritation of treated areas; or
  • worsened symptoms or no improvement in psoriasis.

Using calcitriol topical can affect your body's ability to metabolize calcium. This can result in high levels of calcium in your blood (hypercalcemia). Symptoms of this condition include nausea, constipation, loss of appetite, increased thirst and urination, muscle weakness, confusion, and feeling tired or restless. Call your doctor if you have any of these symptoms.

Less serious side effects may include mild itching or skin discomfort.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Vectical Ointment (calcitriol ointment) Side Effects Center for a complete guide to possible side effects

Learn More »

What is the most important information I should know about calcitriol topical (Vectical Ointment)?

You should not use this medication if you have a severe form of psoriasis (with pus, skin peeling, severe redness).

Before using calcitriol topical, tell your doctor if you have low or high levels of calcium in your blood, a calcium disorder or metabolic imbalance, or if you are receiving UV light treatments (phototherapy) for your psoriasis.

Tell your doctor about all other medicines you are using to treat psoriasis. Also tell your doctor if you are taking a diuretic (water pill) or vitamin or mineral supplements that contain calcium or vitamin D.

Calcitriol topical is for use only on areas of psoriasis. Avoid getting it on healthy skin areas. Calcitriol topical should not be applied to the face or the vaginal area.

Stop using this medication and call your doctor if you have a serious side effect such as blistering or severe redness, itching, or other irritation of treated skin.

Using calcitriol topical can affect your body's ability to metabolize calcium. This can result in high levels of calcium in your blood (hypercalcemia). Symptoms of this condition include nausea, loss of appetite, constipation, increased thirst and urination, muscle weakness, confusion, and feeling tired or restless. Call your doctor if you have any of these symptoms.

Side Effects Centers
  • Vectical

Patient Detailed How Take

What should I discuss with my healthcare provider before using calcitriol topical (Vectical Ointment)?

You should not use this medication if you have a severe form of psoriasis (with pus, skin peeling, severe redness).

To make sure you can safely use calcitriol topical, tell your doctor if you have any of these other conditions:

  • low or high levels of calcium in your blood;
  • a calcium disorder or metabolic imbalance; or
  • if you are receiving UV light treatments (phototherapy) for your psoriasis.

FDA pregnancy category C. It is not known whether calcitriol topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known if calcitriol topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not use this medication on anyone under 18 years old without medical advice.

How should I use calcitriol topical (Vectical Ointment)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Calcitriol topical is usually applied once in the morning and once in the evening. Follow your doctor's instructions.

Do not share this medication with other people, even if they have the same symptoms you have.

Wash your hands before and after applying this medicine.

Apply a thin layer of the medication and rub it in completely.

Do not cover treated skin areas unless your doctor has told you to.

Calcitriol topical is for use only on areas of psoriasis. Avoid getting it on healthy skin areas.

Calcitriol topical should not be applied to the face or the vaginal area.

Store at room temperature away from moisture and heat. Do not allow the medicine to freeze.

Side Effects Centers
  • Vectical

Patient Detailed Avoid Taking

What happens if I miss a dose (Vectical Ointment)?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose (Vectical Ointment)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, weakness, or confusion.

What should I avoid while using calcitriol topical (Vectical Ointment)?

Avoid exposing treated skin areas to sunlight or tanning beds. Calcitriol topical can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Avoid getting this medication in your eyes or mouth, or on your lips. If this does happen, rinse with water.

What other drugs will affect calcitriol topical (Vectical Ointment)?

Tell your doctor about all other medicines you use, especially:

  • other medicines to treat psoriasis;
  • vitamin or mineral supplements that contain calcium or vitamin D; or
  • a diuretic (water pill) such as chlorothiazide (Diuril), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others.

This list is not complete and other drugs may interact with calcitriol topical. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about calcitriol topical.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 2.01. Revision date: 3/9/2012.

Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.

Healthwise

Side Effects Centers
  • Vectical

Rx Scoops
Featured Topics
Advertisements
Copyrights ©2014: Rx Scoops - Designed & Developed By - GOIGI