Supplements Details

Chondroitin Sulfate

What other names is Chondroitin Sulfate known by?

Calcium Chondroitin Sulfate, CDS, Chondroitin, Chondroitin Polysulfate, Chondroitin Polysulphate, Chondroitin Sulfate A, Chondroitin Sulfates, Chondroitin Sulfate B, Chondroitin Sulfate C, Chondroitin Sulphates, Chondroitin Sulphate A Sodium, Chondroïtine, Chondroïtine Sulfate A, Chondroïtine Sulfate B, Chondroïtine Sulfate C, Chondroïtine 4-sulfate, Chondroïtine 4- et 6- sulfate, Condroitin, CPS, CS, CSA, CSC, GAG, Galactosaminoglucuronoglycan Sulfate, Chondroitin 4-sulfate, Chondroitin 4- and 6-sulfate, Poly-(1->3)-N-aceltyl-2-amino-2-deoxy-3-O-beta-D-glucopyranurosyl-4-(or 6-), Polysulfate de Chondroïtine, Sulfate de Chondroïtine, Sulfate de Galactosaminoglucuronoglycane, Sulfates de Chondroïtine, Sulfato de Condroitina.

What is Chondroitin Sulfate?

Chondroitin sulfate is a chemical that is normally found in cartilage around joints in the body. Chondroitin sulfate is manufactured from animal sources such as cow cartilage.

Is Chondroitin Sulfate effective?

When used with conventional anti-inflammatory medications such as ibuprofen (Advil, Motrin, etc.), chondroitin sulfate seems to help reduce hip and knee joint pain due to a type of arthritis known as osteoarthritis. It can take up to 4 months of treatment for relief of pain.

Chondroitin sulfate is often sold in combination products that also contain glucosamine sulfate. So far, there is no evidence that the combination products work any better than either chondroitin sulfate or glucosamine sulfate alone. Buying a combination product is probably not worth any extra cost.

There isn't enough information to know if chondroitin sulfate is effective for other conditions people use it for, including: heart disease, osteoporosis (weak bones), or high cholesterol.

Possibly Effective for...

  • Dry eyes as an eye drop.
  • Reducing pain from a kind of arthritis called osteoarthritis.

Insufficient Evidence to Rate Effectiveness for...

  • Heart disease, osteoporosis (weak bones), high cholesterol, and other conditions.

How does Chondroitin Sulfate work?

In osteoarthritis, the cartilage in the joints breaks down. Taking chondroitin sulfate, one of the building blocks of cartilage, might slow this breakdown.

Are there safety concerns?

Chondroitin sulfate seems to be safe for most people. It can cause some mild stomach pain and nausea. Other side effects that have been reported are diarrhea, constipation, swollen eyelids, leg swelling, hair loss, and irregular heartbeat.

There is some concern about the safety of chondroitin sulfate because it comes from animal sources. Some people are worried that unsafe manufacturing practices might lead to contamination of chondroitin products with diseased animal tissues including those that might transmit bovine spongiform encephalopathy (mad cow disease). So far, there are no reports of chondroitin causing disease in humans, and the risk is thought to be low.

Some chondroitin products contain excess amounts of manganese. Ask your healthcare professional about reliable brands.

Do not use chondroitin sulfate if:

  • You are pregnant or breast-feeding.
  • You have asthma.
  • You have prostate cancer or an increased risk for prostate cancer.

Are there any interactions with medications?



Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting. There are several reports showing that taking chondroitin with glucosamine increases the effect of warfarin (Coumadin) on blood clotting. This can cause bruising and bleeding that can be serious. Don't take chondroitin if you are taking warfarin (Coumadin).

Dosing considerations for Chondroitin Sulfate.

The following doses have been studied in scientific research:

BY MOUTH:

  • For osteoarthritis: the typical dose of chondroitin sulfate is 200-400 mg two to three times daily or 1000-1200 mg as a single daily dose.

APPLIED TO THE SKIN:

  • For osteoarthritis: a cream containing 50 mg/g of chondroitin sulfate, 30 mg/g of glucosamine sulfate, 140 mg/g of shark cartilage, and 32 mg/g of camphor has been used as needed for sore joints for up to 8 weeks.

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