Supplements Details

Coenzyme Q-10

What other names is Coenzyme Q-10 known by?

Co Q10, Co Q-10, Coenzima Q-10, Co-Enzyme 10, Coenzyme Q 10, Coenzyme Q10, Co-Enzyme Q10, Co-Enzyme Q-10, Co-Q 10, CoQ10, Co-Q10, CoQ-10, Ubidcarenone, Ubidécarénone, Ubiquinone-10.

What is Coenzyme Q-10?

Coenzyme Q-10 (CoQ-10) is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas. It is eaten in small amounts in meats and seafood. Coenzyme Q-10 can also be made in a laboratory. It is used as medicine.

Likely Effective for...

  • Coenzyme Q-10 deficiency (very rare).
  • Mitochondrial disorders, inherited or acquired disorders that limit energy production in the cells of the body.

Possibly Effective for...

  • Congestive heart failure (CHF), in combination with other medications.
  • Decreasing the risk of additional heart problems in people who have had a recent heart attack (myocardial infarction).
  • Huntington's disease.
  • Preventing blood vessel complications caused by heart bypass surgery.
  • High blood pressure (hypertension) in combination with other medications.
  • Preventing migraine headache.
  • Parkinson's disease. Some research shows that taking coenzyme Q-10 supplements might slow functional decline in people with early Parkinson's disease. But taking a coenzyme Q-10 supplement in people with mid-stage Parkinson's disease does not seem to improve symptoms.
  • Improving the immune system of people with HIV/AIDS.
  • Muscular dystrophy, an inherited disorder involving muscle wasting.

Likely Ineffective for...

  • Improving exercise performance.
  • Dental (periodontal) disease, when applied directly to the teeth and gums.

Insufficient Evidence to Rate Effectiveness for...

  • Improving blood sugar control in people with diabetes, breast cancer, fatigue, Lyme disease, male infertility, chest pain (angina), a muscle condition called "statin-induced myopathy," cardiomyopathy in children and adults, and other conditions.

How does Coenzyme Q-10 work?

Coenzyme Q-10 is an important vitamin-like substance required for the proper function of many organs and chemical reactions in the body. It helps provide energy to cells. Coenzyme Q-10 also seems to have antioxidant activity. People with certain diseases, such as congestive heart failure, high blood pressure, periodontal disease, Parkinson's disease, certain muscular diseases, and AIDS, might have lower levels of coenzyme Q-10.

Are there safety concerns?

Coenzyme Q-10 is safe for most adults. While most people tolerate coenzyme Q-10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure. Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help reduce side effects.

Coenzyme Q-10 also seems to be safe for most children. But coenzyme Q-10 should not be used in children without medical supervision.

Do not use coenzyme Q-10 if:

  • You are pregnant or breast-feeding.
  • You are scheduled for surgery in the next two weeks.

Are there any interactions with medications?



Medications for cancer (Chemotherapy)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Coenzyme Q-10 is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. But it is too soon to know if the interaction occurs.



Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Coenzyme Q-10 seems to decrease blood pressure. Taking coenzyme Q-10 along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.



Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting while coenzyme Q-10 might increase blood clotting. By helping the blood clot, coenzyme Q-10 might decrease the effectiveness of warfarin (Coumadin) and increase the risk of dangerous clots. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Dosing considerations for Coenzyme Q-10.

The following doses have been studied in scientific research:

BY MOUTH:

  • For known coenzyme Q-10 deficiency: 150 mg daily.
  • For mitochondrial disorders (mitochondrial encephalomyopathies): 150-160 mg, or 2 mg/kg/day. In some cases, doses may be gradually increased to 3000 mg per day.
  • For heart failure in adults: 100 mg per day divided into 2 or 3 doses.
  • For reducing the risk of future cardiac events in patients with recent myocardial infarction: 120 mg daily in 2 divided doses.
  • For high blood pressure: 120-200 mg per day divided into 2 doses.
  • For isolated systolic hypertension: 60 mg twice daily.
  • For preventing migraine headache: 100 mg three times daily. A dose of 1-3 mg/kg has also been used in pediatric and adolescent patients.
  • For Parkinson's disease: 300 mg, 600 mg, 1200 mg, and 2400 mg per day in 3-4 divided doses.
  • For HIV/AIDS: 200 mg per day.
  • For infertility in men: 200-300 mg per day.
  • For muscular dystrophy: 100 mg per day.
  • For pre-eclampsia: 100 mg twice daily starting at week 20 of pregnancy until delivery.

Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help reduce side effects.

Rx Scoops
Featured Topics
Advertisements
Copyrights ©2014: Rx Scoops - Designed & Developed By - GOIGI